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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 201 - 207 (7page)
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Alternations in usage of polyadenylation sites during transcription termination yield transcript isoforms from a gene.
Recent findings of transcriptome-wide alternative polyadenylation (APA) as a molecular response to changes in biology position APA not only as a molecular event of early transcriptional termination but also as a cellular regulatory step affecting various biological pathways. With the development of high-throughput profiling technologies at a single nucleotide level and their applications targeted to the 3’-end of mRNAs, dynamics in the landscape of mRNA 3’-end is measureable at a global scale. In this review, methods and technologies that have been adopted to study APA events are discussed. In addition, various bioinformatics algorithms for APA isoform analysis using publicly available RNA-seq datasets are introduced.
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참고문헌 (27)
참고문헌 신청
Alt FW / 1980 / Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3’ ends / Cell 20 : 293 ~ 301
Beaudoing E / 2000 / Patterns of Variant Polyadenylation Signal Usage in Human Genes / Genome Res 10 : 1001 ~ 1010
Chang J / 2015 / mRNA 3prime]- UTR shortening is a molecular signature of mTORC1 activation / Nat Commun 6 : 7218 ~
Colgan DF / 1997 / Mechanism and regulation of mRNA polyadenylation / Genes Dev 11 : 2755 ~ 2766
Danckwardt S / 2007 / Splicing factors stimulate polyadenylation via USEs at noncanonical 3’ end formation signals / EMBO J 26 : 2658 ~ 2669
Beaudoing E / 2000 / Patterns of Variant Polyadenylation Signal Usage in Human Genes / Genome Res 10 : 1001 ~ 1010
Chang J / 2015 / mRNA 3prime]- UTR shortening is a molecular signature of mTORC1 activation / Nat Commun 6 : 7218 ~
Colgan DF / 1997 / Mechanism and regulation of mRNA polyadenylation / Genes Dev 11 : 2755 ~ 2766
Danckwardt S / 2007 / Splicing factors stimulate polyadenylation via USEs at noncanonical 3’ end formation signals / EMBO J 26 : 2658 ~ 2669
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