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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 230 - 235 (6page)
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초록· 키워드
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Bone resorption by multinucleated osteoclasts is a multistep process involving adhesion to the bone matrix, migration to resorption sites, and formation of sealing zones and ruffled borders. Macrophage colony-stimulating factor (M-CSF) and osteopontin (OPN) have been shown to be involved in the bone resorption process by respective activation of integrin αvβ3 via "inside-out" and "outside-in" signaling. In this study, we investigated the link between signal modulators known to M-CSF- and OPN-induced osteoclast adhesion and spreading. M-CSF- and OPN-induced osteoclast adhesion was achieved via activation of stepwise signals, including integrin αvβ3, PLCγ, PKCδ, and Rac1. Osteoclast spreading induced by M-CSF and OPN was shown to be controlled via sequential activation, consistent with the osteoclast adhesion processes. In contrast to osteoclast adhesion, osteoclast spreading induced by M-CSF and OPN was blocked via activation of PLCγ/PKCα/RhoA signaling. The combined results indicate that osteoclast adhesion and spreading are selectively regulated via PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling.
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참고문헌 (29)
참고문헌 신청
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Touaitahuata H / 2014 / Modulation of osteoclast differentiation and bone resorption by Rho GTPases / Small GTPases 5:e28119
Georgess D / 2014 / Podosome organization drives osteoclast-mediated bone resorption / Cell Adh Migr 8:191~204
Raggatt LJ / 2010 / Cellular and molecular mechanisms of bone remodeling / J Biol Chem 285:25103~25108
Faccio R / 2003 / Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin / J Cell Biol 162:499~509
Touaitahuata H / 2014 / Modulation of osteoclast differentiation and bone resorption by Rho GTPases / Small GTPases 5:e28119
Georgess D / 2014 / Podosome organization drives osteoclast-mediated bone resorption / Cell Adh Migr 8:191~204
Raggatt LJ / 2010 / Cellular and molecular mechanisms of bone remodeling / J Biol Chem 285:25103~25108
Faccio R / 2003 / Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin / J Cell Biol 162:499~509
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