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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 472 - 477 (6page)
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The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of the network of factors that regulates interleukin-2 expression. In primary and transformed CD4＋ T cells, Bach2 overexpression counteracted T cell receptor/CD28- or PMA/ ionomycin-driven induction of interleukin-2 expression, and silencing of Bach2 had the opposite effect. Luciferase and chromatin immunoprecipitation assays revealed that Bach2 binds to multiple Maf-recognition element-like sites on the interleukin-2 proximal promoter in a manner competitive with AP-1, and thereby represses AP-1-driven induction of interleukin-2 transcription. Thus, this study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in CD4＋ T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state.
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참고문헌 (24)
참고문헌 신청
Chen R / 2014 / In vivo RNA interference screens identify regulators of antiviral CD4＋ and CD8＋ T cell differentiation / Immunity 41 : 325 ~ 338
Choi YB / 1999 / Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation / J Immunol 163 : 5242 ~ 5249
Choi YS / 2015 / LEF-1 and TCF-1 orch
Cooper JD / 2008 / Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci / Nat Genet 40 : 1399 ~ 1401
Ferreira MA / 2011 / Identification of IL6R and chromosome 11q13. 5 as risk loci for asthma / Lancet 378 : 1006 ~ 1014
Choi YB / 1999 / Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation / J Immunol 163 : 5242 ~ 5249
Choi YS / 2015 / LEF-1 and TCF-1 orch
Cooper JD / 2008 / Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci / Nat Genet 40 : 1399 ~ 1401
Ferreira MA / 2011 / Identification of IL6R and chromosome 11q13. 5 as risk loci for asthma / Lancet 378 : 1006 ~ 1014
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