지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 560 - 565 (6page)
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초록· 키워드
오류제보하기
Geraniin, a hydrolysable tannin, used in traditional medicine in Southeast Asia, is known to exhibit various biological activities. As an antioxidant it is known to up-regulate phase II enzyme Heme oxygenase-1 (HO-1). However its mechanism is not clearly understood. Nuclear factor erythroid-derived 2 related factor 2 (Nrf-2) is transcriptionally up-regulated by Extracellular signal-regulated kinase (ERK) 1/2 and retained in nucleus due to inactivated Glycogen synthase kinase 3 beta (GSK-3β). Geraniin additionally down-regulates expression of microRNA 217 and 377 (miR-217 and miR-377) which target HO-1 mRNA. Expression of BTB and CNC homolog 1 (BACH-1), another regulator of HO-1, is also down-regulated by up-regulating microRNA 98 (miR-98), a negative regulator of BACH-1. Thus, geraniin up-regulates HO-1 expression both through activating its positive regulator Nrf-2 and by down-regulating its negative regulator BACH-1. Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Beckman JD / 2011 / Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217 / J Biol Chem 286 : 3194 ~ 3202
Cadenas E / 1997 / Basic mechanisms of antioxidant activity / Biofactors 6 : 391 ~ 397
Dalle-Donne I / 2006 / Biomarkers of oxidative damage in human disease / Clin Chem 52 : 601 ~ 623
Dhakshinamoorthy S / 2005 / Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)- mediated NAD(P)H:quinone oxidoreductase 1 gene
Droge W / 2002 / Free radicals in the physiological control of cell function / Physiol Rev 82 : 47 ~ 95
Cadenas E / 1997 / Basic mechanisms of antioxidant activity / Biofactors 6 : 391 ~ 397
Dalle-Donne I / 2006 / Biomarkers of oxidative damage in human disease / Clin Chem 52 : 601 ~ 623
Dhakshinamoorthy S / 2005 / Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)- mediated NAD(P)H:quinone oxidoreductase 1 gene
Droge W / 2002 / Free radicals in the physiological control of cell function / Physiol Rev 82 : 47 ~ 95
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