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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 618 - 623 (6page)
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FK506 binding protein 12 (FK506BP) is a small peptide with a single FK506BP domain that is involved in suppression of immune response and reactive oxygen species. FK506BP has emerged as a potential drug target for several inflammatory diseases. Here, we examined the protective effects of directly applied cell permeable FK506BP (PEP-1-FK506BP) on corneal alkali burn injury (CAI). In the cornea, there was a significant decrease in the number of cells expressing pro-inflammation, apoptotic, and angiogenic factors such as TNF-α, COX-2, and VEGF. Both corneal opacity and corneal neovascularization (CNV) were significantly decreased in the PEP-1-FK506BP treated group. Our results showed that PEP-1-FK506BP can significantly inhibit alkali burn-induced corneal inflammation in rats, possibly by accelerating corneal wound healing and by reducing the production of angiogenic factors and inflammatory cytokines.
These results suggest that PEP-1-FK506BP may be a potential therapeutic agent for CAI.
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참고문헌 (46)
참고문헌 신청
김대원 / 2013 / Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model / BMB Reports 46(2):124~129
Kim SY / 2011 / Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice / J Invest Dermatol 131:1477~1485
Song HY / 2008 / Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoyl phorbol-13-acetate(TPA)-induced inflammation in mice / Biochem Pharmacol 75:1348~1357
He J / 2006 / Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist / Arch Ophthalmol 124:70~78
Ma Y / 2006 / Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells / Stem Cells 24:315~321
Kim SY / 2011 / Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice / J Invest Dermatol 131:1477~1485
Song HY / 2008 / Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoyl phorbol-13-acetate(TPA)-induced inflammation in mice / Biochem Pharmacol 75:1348~1357
He J / 2006 / Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist / Arch Ophthalmol 124:70~78
Ma Y / 2006 / Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells / Stem Cells 24:315~321
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