지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 313 - 318 (6page)
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초록· 키워드
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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade the extracellular matrix (ECM) and regulate the extracellular microenvironment. Despite the significant role that MMP activity plays in cell-cell and cell-ECM interactions, migration, and differentiation, analyses of MMPs in vitro and in vivo have relied upon their abundance using conventional immunoassays, rather than their enzymatic activities.
To resolve this issue, diverse nanoprobes have emerged and proven useful as effective activity-based detection tools.
Here, we review the recent advances in luminescent nanoprobes and their applications in in vitro diagnosis and in vivo imaging of MMP activity. Nanoprobes with the purpose of sensing MMP activity consist of recognition and detection units, which include MMP-specific substrates and luminescent (fluorescent or bioluminescent) nanoparticles, respectively.
With further research into improvement of the optical performance, it is anticipated that luminescent nanoprobes will have great potential for the study of the functional roles of proteases in cancer biology and nanomedicine.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Achatz DE / 2009 / Probing the activity of matrix metalloproteinase II with a sequentially click-labeled silica nanoparticle FRET probe / Chem Biochem 10 : 2316 ~ 2320
Alivisatos P / 2004 / The use of nanocrystals in biological detection / Nat Biotechnol 22 : 47 ~ 52
Bremer C / 2001 / Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model / Radiology 221 : 523 ~ 529
Bruchez M Jr / 1998 / Semiconductor nanocrystals as fluorescent biological labels / Science 281 : 2013 ~ 2016
Butler GS / 2009 / Updated biological roles for matrix metalloproteinases and new"intracellular"substrates revealed by degradomics / Biochemistry 48 : 10830 ~ 10845
Alivisatos P / 2004 / The use of nanocrystals in biological detection / Nat Biotechnol 22 : 47 ~ 52
Bremer C / 2001 / Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model / Radiology 221 : 523 ~ 529
Bruchez M Jr / 1998 / Semiconductor nanocrystals as fluorescent biological labels / Science 281 : 2013 ~ 2016
Butler GS / 2009 / Updated biological roles for matrix metalloproteinases and new"intracellular"substrates revealed by degradomics / Biochemistry 48 : 10830 ~ 10845
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