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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 7 (7page)
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Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of MMP1 mRNA is downregulated by the overexpression of miR-526b which is a member of chromosome 19 microRNA cluster (C19MC). Our analysis using reporter constructs containing the 3′ untranslated region (3′ UTR) of MMP1 and its mutant form showed that the region from 377–383 in the 3′ UTR of MMP1 is critical for targeting by miR-526b. In addition, the expression pattern of miR-526b and MMP1 mRNA showed reverse relation between adult dermal and neonatal fibroblasts. We show for the first time that miR-526b, an miRNA belonging to C19MC, can target the 377–383 region of the MMP1 3′ UTR.
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참고문헌 (20)
참고문헌 신청
Aberdam D / 2008 / miRNAs, 'stemness' and skin / Trends Biochem Sci 33 : 583 ~ 591
Borchert GM / 2006 / RNA polymerase III transcribes human microRNAs / Nat Struct Mol Biol 13 : 1097 ~ 1101
Bortolin-Cavaille ML / 2009 / C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts / Nucleic Acids Res 37 : 3464 ~ 3473
Brenneisen P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases : from induction via signaling to initial events / Ann N Y Acad Sci 973 : 31 ~ 43
Fanjul-Fernandez M / 2013 / Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflamm
Borchert GM / 2006 / RNA polymerase III transcribes human microRNAs / Nat Struct Mol Biol 13 : 1097 ~ 1101
Bortolin-Cavaille ML / 2009 / C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts / Nucleic Acids Res 37 : 3464 ~ 3473
Brenneisen P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases : from induction via signaling to initial events / Ann N Y Acad Sci 973 : 31 ~ 43
Fanjul-Fernandez M / 2013 / Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflamm
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