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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 302 - 307 (6page)
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Pinosylvin is known to have anti-inflammatory activity in endothelial cells. In this study, we found that pinosylvin had a pro-apoptotic activity in lipopolysaccharide (LPS)-preconditioned leukocytes. This finding suggests that pinosylvin has an effect on the resolution of inflammation. To understand the detailed mechanism, we examined if pinosylvin enhances cyclooxygenase (COX) or lipoxygenase (LOX) activity in THP-1 and U937 cells. LOX activity was found to be markedly increased by pinosylvin, whereas COX activity was not altered. Furthermore, we found that pinosylvin enhanced both levels of ALOX 15 mRNA and protein, implying that LOX activity, elevated by pinosylvin, is attributed to upregulation of ALOX 15 expression. From this cell signaling study, pinosylvin appeared to promote phosphorylations of ERK and JNK. ERK or JNK inhibitors were found to attenuate ALOX 15 expression and LPS-induced apoptosis promoted by pinosylvin. In conclusion, pinosylvin enhances the apoptosis of LPSpreconditioned leukocytes by up-regulating ALOX 15 expression through ERK and JNK. These findings suggest that pinosylvin may induce the resolution of inflammation.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Ashley NT / 2012 / Inflammation: Mechanisms, Costs, and Natural Variation / Annu Rev Ecol Evol Syst 43:385~406
Cascao R / 2009 / Neutrophils: warriors and commanders in immune mediated inflammatory diseases / Acta Reumatol Port 34:313~326
Cascao R / 2010 / Neutrophils in rheumatoid arthritis: More than simple final effectors / Autoimmun Rev 9:531~535
Fialkow L / 2007 / Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function / Free Rad Biol Med 42:153~164
Wright HL / 2010 / Neutrophil function in inflammation and inflammatory diseases / Rheumatology 49:1618~1631
Cascao R / 2009 / Neutrophils: warriors and commanders in immune mediated inflammatory diseases / Acta Reumatol Port 34:313~326
Cascao R / 2010 / Neutrophils in rheumatoid arthritis: More than simple final effectors / Autoimmun Rev 9:531~535
Fialkow L / 2007 / Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function / Free Rad Biol Med 42:153~164
Wright HL / 2010 / Neutrophil function in inflammation and inflammatory diseases / Rheumatology 49:1618~1631
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