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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 36 - 41 (6page)
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Recently, we demonstrated that human serum amyloid Pcomponent (SAP) specifically recognizes exposed bacterialpeptidoglycan (PGN) of wall teichoic acid (WTA)-deficientStaphylococcus aureus ΔtagO mutant cells and then inducescomplement-independent phagocytosis. In our preliminaryexperiments, we found the existence of human serumimmunoglobulins that recognize S. aureus PGN (anti-PGNIgGs),which may be involved in complement-dependentopsonophagocytosis against infected S. aureus cells. Weassumed that purified serum anti-PGN-IgGs and S. aureusΔtagO mutant cells are good tools to study the molecularmechanism of anti-PGN-IgG-mediated phagocytosis. Therefore,we tried to identify the intracellular molecule(s) that is involvedin the anti-PGN-IgG-mediated phagocytosis using purifiedhuman serum anti-PGN-IgGs and different S. aureus mutantcells. Here, we show that anti-PGN-IgG-mediated phagocytosisin phorbol myristate acetate-treated U937 cells is mediated byCa2+ release from intracellular Ca2+ stores and anti-PGN-IgGdependentCa2+ mobilization is controlled via a phospholipaseCγ-2-mediated pathway.
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참고문헌 (23)
참고문헌 신청
[학술지(
Aki D / 2008 / Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells / Genes Cells 13 : 199 ~ 2
Akira S / 2003 / Mammalian Toll-like receptors / Curr Opin Immunol 15 : 5 ~ 11
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
An JH / 2013 / Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus / J Immunol 191 : 3319 ~ 3327
Aki D / 2008 / Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells / Genes Cells 13 : 199 ~ 2
Akira S / 2003 / Mammalian Toll-like receptors / Curr Opin Immunol 15 : 5 ~ 11
Akira S / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
An JH / 2013 / Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus / J Immunol 191 : 3319 ~ 3327
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