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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 26 - 36 (11page)
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Objectives In this study, effect of Geumsuyukgunjeon (GYJ) on the increase in airway epithelial mucosubstances of rats with acute bronchitis and EGF-induced MUC5AC mucin production from human airway epithelial cells were investigated.
Materials and Methods Hypersecretion of airway mucus was induced by exposure of rats to SO2 during 3 weeks. Effect of orally-administered GYJ during 2 weeks on increase in airway epithelial mucosubstances from tracheal goblet cells of rats was assesed using histopathological analysis after staining the epithelial tissue with PAS-alcian blue. Possible cytotoxicity of GYJ was assessed by examining the potential damage of kidney and liver functions by measuring serum GOT/GPT activities and serum BUN and creatinine concentrations of rats and the body weight gain during experiment, after administering GYJ orally. Effect of GYJ on EGF-induced MUC5AC mucin production from human airway epithelial cells (A549) was investigated.
Confluent A549 cells were pretreated for 30 min in the presence of GYJ and treated with EGF (25 ng/ml) for 24 hrs, to assess the effect of GYJ on EGF-induced MUC5AC mucin production using enzyme-linked immunosorbent assay (ELISA).
Results (1) GYJ decreased the amount of intraepithelial mucosubstances of trachea of rats. (2) GYJ did not show kidney and liver toxicities and did not affect body weight gain of rats during experiment. (3) GYJ significantly inhibited EGF-induced MUC5AC mucin production from A549 cells.
Conclusions The result from the present study suggests that GYJ might control both the mucus hypersecretion in vivo and do not show in vivo toxicity to liver and kidney functions after oral administration and the production of pulmonary mucin.
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참고문헌 (36)
참고문헌 신청
Hoorens PR / 2011 / Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile / BMC Genomics 12:140
Rousseau K / 2007 / Muc5b and muc5a are the major oligomeric mucins in equine airway mucus / Am J Physiol Lung Cell Mol Physiol 292:1396~1404
Shim JJ / 2000 / Suplatast tosilate inhibits goblet-cell metaplasia of airway epithelium in sensitized mice / J Allergy Clin Immunol 105:739~745
Jung HJ / 1995 / Review of literatures about sputum on west-oriental medicine / J Orient Chronic Dis 1(1):51~62
Lee SI / 1986 / Hanyakilmsangyeongyong / Sungbosa :355~356
Rousseau K / 2007 / Muc5b and muc5a are the major oligomeric mucins in equine airway mucus / Am J Physiol Lung Cell Mol Physiol 292:1396~1404
Shim JJ / 2000 / Suplatast tosilate inhibits goblet-cell metaplasia of airway epithelium in sensitized mice / J Allergy Clin Immunol 105:739~745
Jung HJ / 1995 / Review of literatures about sputum on west-oriental medicine / J Orient Chronic Dis 1(1):51~62
Lee SI / 1986 / Hanyakilmsangyeongyong / Sungbosa :355~356
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