홍조 유무에 따른 일반혈액검사 수치의 과음 예측도

정현철; 양현주; 김종성; 김성수; 윤석준; 장영위

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자료유형: 학술저널

저자정보: 정현철 양현주 김종성 김성수 윤석준 장영위

저널정보: 대한임상건강증진학회 Korean Journal of Health Promotion Korean Journal of Health Promotion 제16권 제2호

발행연도: 2016.1

수록면: 84 - 91 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

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연구배경: 본 연구는 CBC 수치와 과음의 연관성에 대해서 알아보고자 하였다. 방법: 2013년 6월부터 12월까지 충남대학교병원에서 종합검진을 받은 수검자 중 581명의 한국 성인 남성을 대상으로 하였다. 비음주자는 98명, 음주 관련 안면홍조자 225 명, 비홍조자 258명이었다. 음주량은 14 g을 표준 1잔으로적용하였다. 과음에 대한 기준은 한국 가이드라인(Korean guideline)과 미국 가이드라인(NIAAA)을 참조하여 비홍조군에 대해서는 8잔 초과 및 14잔 초과를 적용하였고, 홍조군에 대해서는 4잔 초과 및 7잔 초과를 적용하였다. MCV 증가, Hb 감소, PLT 감소가 과음을 어느 정도 예측하는지조사하였다. 결과: MCV 증가, Hb 감소, PLT 감소 중 하나에 해당할경우 NIAAA guideline 기준의 과음에 대한 예측도는 홍조군 23.1%, 비홍조군 21.7%를 보였고, Korean guideline 기준의 과음에 대한 예측도는 홍조군 30.8%, 비홍조군 30.4% 를 보였다. MCV 증가, Hb 감소, PLT 감소 중 어느 항목이라도 두 개에 만족할 경우 NIAAA guideline 기준의 과음예측도는 홍조군 100%, 비홍조군 100%였고, Korean guideline 기준의 과음 예측도는 홍조군 100%, 비홍조군100%였다. 결론: 임상에서 CBC 수치를 과음 예측 지표로 사용할경우 MCV 증가, Hb 감소, PLT 감소의 조합을 사용하는것이 바람직함을 알 수 있었다.

Background: Alcohol is personal and social problem around the world. Though binge drinking is associated with the elevation of arbohydrate deficient trasnferrin and r-glutamyl transpeptidase, studies of the relationship between heavy drinking and other biological markers are rare. The purpose of this study is to investigate the association between heavy drinking and CBC figures through flushing and non flushing using both NIAAA and Korean guidelines. Methods: The subjects were 581 Korean adult males: who had undergone a comprehensive medical evaluation at Chungnam National University Hospital between June and December of 2013. 98 of total were non-drinkers, 225 of them flushers, and the rest 258 of them were non-flushers. One standard drink is defined as any drink that contains 14 grams of alcohol. Criteria for immoderate drinking was applied to greater than 14 glasses/week and more than 8 glasses on any day for a non-flush group with reference to the United States’ guideline (National Institute in Alcohol Abuse and Alcoholism, NIAAA) and South Korean guideline, and it was also applied to greater than seven glasses/week, and more than four glasses on any day for a flushing group. It was to investigate whether immoderate drinking would be predictable according to increased mean corpuscular volume (MCV), decreased hemoglobin (Hb), and decreased platelet (PLT). Our investigation was to find the correlation with the increased MCV, decreased Hb, and decreased PLT as a means of predictions for immoderate drinking. The study was to examine the CBC's predictability of immoderate drinking through a combination of increased MCV, decreased Hb, or decreased PLT. If one of these three items were abnormal: group A, if two of the three items were abnormal: group B. Results: Predictability of group A was 23.1% in flushing drinkers and 21.7% in non-flushing drinkers for US NIAAA immoderate drinking, whereas 30.8% in flushing drinkers and 30.4% in non-flushing drinkers considering Korean guideline immoderate drinking. Predictability of B group was 100% in flushing and non-flushing drinkers for both NIAAA guidelines and Korean guidelines. Conclusions: It is desirable for physicians to use any combination of the three CBC indicators (increased MCV, decreased Hb, or decreased PLT) for predicting immoderate drinking.

#알코올 #음주 #국립 알코올 남용 및 중독연구소 #Alcohol #Drinking #NIAAA

참고문헌 (22)

참고문헌 신청

Ward RJ / 1994 / Identification and characterization of alcohol-induced flushing in Caucasian subjects / Alcohol Alcohol 29(4):433~438

Agarwal DP / 1981 / Racial differences in biological sensitivity to ethanol: the role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes / Alcohol Clin Exp Res 5(1):12~16

Ehrig T / 1990 / Alcohol and aldehyde dehydrogenase / Alcohol Alcohol 25(2-3):105~116

Yin SJ / 1992 / Genetic polymorphism and activities of human lung alcohol and aldehyde dehydrogenases: implications for ethanol metabolism and cytotoxicity / Biochem Genet 30(3-4):203~215

Harada S / 1980 / Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese:isozyme variation and its possible role in alcohol intoxication / Am J Hum Genet 32(1):8~15

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