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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한뇌졸중학회 대한뇌졸중학회지 대한뇌졸중학회지 제3권 제2호
발행연도
2001.1
수록면
131 - 136 (6page)

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Background and Objectives : In patient with acute ischemic stroke, there are no conclusive results on the change of lipid profiles during disease course. The aim of this study was to evaluate the changes of lipid profiles in patients with ischemic stroke and to know the lipid change as a response of acute phase reactant. Method : We studied 52 consecutive patients with ischemic stroke admitted to Paik Hospital, Pusan(M:F=36:16, mean age=57.5 ranged 30 to 81 ). Serum lipid(HDL, LDL, TG, TC, Lp(a)) and acute phase reactant(haptoglobin, CRP) were measured at admission and one month later stroke onset. According to the Inje Stroke Registry, we evaluated risk factors, such as hematologic examination, smoking habit, the amount of alcohol consumption, imaging study(CT or MRI), angiography(MRA or conventional ), TCD, and carotid sonography. On the basis of above informations, we classified stroke according to the TOAST classification. The size of infarctions was measured as the largest lesion diameter. Results : Although there is no definite changes of HDL, TC, LDL, LP(a), CRP, and haptoglobin level, the TG level was increased at one month after stroke onset compared to the level of at admission(p=0.015). According to the stroke subtype, the only significant difference is higher TG level at one month after stroke onset compared to the level of at admission in the patients with cardioembolic infarction group(p=0.031). No significant correlation were observed in change of the lipid profiles and acute phase reactant values according to the size of infarction, presence of DM, hypertension, amount of alcohol, and smoking. Conclusion : We did not observe changes of lipid profiles and acute phase reactant except for TG in patients with acute ischemic stroke, especially in the cardioembolic patients. However, because the number of patients with cardioembolic stroke is small, the clinical significance of changing TG level remains unclear. Further studies are required. Korean Journal of Stroke 2001;3(2): 131~136

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