지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 234 - 240 (7page)
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초록· 키워드
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Background/Aims: Ghrelin has recently been reported as exerting a protective effect in the damaged pancreas in rats. We investigated the correlation between severity of acute pancreatitis and serum ghrelin concentrations. Methods: Blood samples were collected three times (at admission, after 48 hours, and at discharge) from patients admitted with acute pancreatitis.
We divided the patients into nonrisk and risk groups. The risk group was defined as the presence of at least one of following risk factors for severe acute pancreatitis: Ranson’s score ≥3, acute physiology and chronic health evaluation (APACHE) II score ≥8, C-reactive protein (CRP) ≥150 mg/L, and CT severity index (CTSI) ≥4. Serum ghrelin concentrations were measured with RIA kit and analyzed based on clinical and biochemical parameters. Results: A total of 53 patients was enrolled in this study: 28 in the nonrisk group and 25 in the risk group. At admission,the ghrelin concentration was significantly higher in the risk group (286.39±272.19 vs 175.96±138.87 pg/mL [mean±SD], p=0.049). However, the ghrelin concentration did not differ significantly between the two groups after 48 hours (p=0.450) and at discharge (p=0.678). The overall ghrelin concentration was significantly lower at admission than at discharge (240.65±247.96 vs 369.41±254.27 pg/mL, p=0.001).
Conclusions: Patients with risk factors for severe acute pancreatitis have higher serum ghrelin concentrations.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Balthazar EJ / 1990 / Acute pancreatitis: value of CT in establishing prognosis / Radiology 174 : 331 ~ 336
Banks PA / 2006 / Practice guidelines in acute pancreatitis / Am J Gastroenterol 101 : 2379 ~ 2400
Cummings DE / 2002 / Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery / N Engl J Med 346 : 1623 ~ 1630
Date Y / 2000 / Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and human
Dembinski A / 2003 / Ghrelin attenuates the development of acute pancreatitis in rat / J Physiol Pharmacol 54 : 561 ~ 573
Banks PA / 2006 / Practice guidelines in acute pancreatitis / Am J Gastroenterol 101 : 2379 ~ 2400
Cummings DE / 2002 / Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery / N Engl J Med 346 : 1623 ~ 1630
Date Y / 2000 / Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and human
Dembinski A / 2003 / Ghrelin attenuates the development of acute pancreatitis in rat / J Physiol Pharmacol 54 : 561 ~ 573
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