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자료유형
학술저널
저자정보
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제9권 제6호
발행연도
2015.1
수록면
741 - 749 (9page)

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Background/Aims: Colorectal adenomas that are ≥10 mm have villous histology or high-grade dysplasia, or that are associated with ≥3 adenomas are considered high-risk for metachronous advanced neoplasia. We evaluated the cumulative incidence of metachronous advanced neoplasia according to the total number of high-risk findings detected on baseline colonoscopy. Methods: This was a retrospective cohort study performed in 862 patients who underwent removal of colorectal adenomas between 2005 and 2009. At least one surveillance colonoscopy had been conducted at Konkuk University Medical Center, Seoul, Korea. Results: The cumulative incidence of metachronous advanced neoplasia in patients with 0, 1, 2, and 3–4 high-risk findings at 1 year were 0.7%, 1.3%, 2.8%, and 8.0%; at 3 years, those were 5.9%, 11.9%, 15.5%, and 24.7%; and at 5 years, those were 8.5%, 18.7%, 26.3%, and 37.2%, respectively. In a multivariate model, the risk of metachronous advanced neoplasia was significantly higher for the multiple high-risk findings group when compared with the 0 high-risk findings group (1 high-risk (+): hazard ratio, 1.86 [95% confidence interval, 1.00–3.44]; 2 high-risk (+): 1.84 [0.88–3.84]; and 3–4 high-risk (+): 3.29 [1.54–7.01]; ptrend=0.020). Conclusions: The presence of overlapping multiple high-risk findings was associated with an increased risk of advanced neoplasia during surveillance.

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