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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 357 - 362 (6page)
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초록· 키워드
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Background/Aims: Ciprofloxacin has been widely prescribed for acute infectious diarrhea. However, the resistance to this drug is increasing. Rifaximin is a novel but poorly absorbed rifamycin derivative. This study evaluated and compared the efficacies of rifaximin and ciprofloxacin for the treatment of acute infectious diarrhea.
Methods: We performed a randomized controlled multicenter study in Korea. Patients with acute diarrhea were enrolled and randomized to receive rifaximin or ciprofloxacin for 3 days. The primary efficacy endpoint was the time to last unformed stool (TLUS). Secondary endpoints were enteric wellness (reduction of at least 50% in the number of unformed stools during 24-hour postenrollment intervals), general wellness (subjective feeling of improvement), and proportion of patients with treatment failure. Results: Intent-to-treat analysis (n=143) showed no significant difference between the rifaximin and ciprofloxacin groups in the mean TLUS (36.1 hours vs 43.6 hours, p=0.163), enteric wellness (49% vs 57%, p=0.428), general wellness (67%vs 78%, p=0.189), or treatment failure rate (9% vs 12%, p=0.841). The adverse events did not differ significantly between the two groups. Conclusions: These results suggest that rifaximin is as safe and effective as ciprofloxacin in the treatment of acute infectious diarrhea.
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참고문헌 (22)
참고문헌 신청
Adachi JA / 2006 / Rifaximin: a novel nonabsorbed rifamycin for gastrointestinal disorders / Clin Infect Dis 42 : 541 ~ 547
Brigidi P / 2002 / Effects of rifaximin administration on the intestinal microbiota in patients with ulcerative colitis / J Chemother 14 : 290 ~ 295
Cheong HJ / 2001 / Bacteremia due to quinolone-resistant Escherichia coli in ateaching hospital in South Korea / Clin Infect Dis 33 : 48 ~ 53
Chong Y / 1998 / Korean Nationwide Surveillance of Antimicrobial Resistance of bacteria in 1997 / Yonsei Med J 39 : 569 ~ 577
De Leo C / 1986 / Rapid disappearance from the intestinal tract of bacteria resistant to rifaximin / Drugs Exp Clin Res 12 : 979 ~ 981
Brigidi P / 2002 / Effects of rifaximin administration on the intestinal microbiota in patients with ulcerative colitis / J Chemother 14 : 290 ~ 295
Cheong HJ / 2001 / Bacteremia due to quinolone-resistant Escherichia coli in ateaching hospital in South Korea / Clin Infect Dis 33 : 48 ~ 53
Chong Y / 1998 / Korean Nationwide Surveillance of Antimicrobial Resistance of bacteria in 1997 / Yonsei Med J 39 : 569 ~ 577
De Leo C / 1986 / Rapid disappearance from the intestinal tract of bacteria resistant to rifaximin / Drugs Exp Clin Res 12 : 979 ~ 981
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