지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 256 - 270 (15page)
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초록· 키워드
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Background/Aims: Ciprofloxacin is considered to be a safeand effective treatment for acute infectious colitis. However,this drug may cause drug-induced pancreatitis, albeit rarely.
Methods: From March 2007 to February 2012, we studied227 patients who were hospitalized for infectious colitis atSt. Mary’s Hospital. All of the patients received ciprofloxacintherapy for the treatment of infectious colitis. We observed afew cases of rare adverse events, including ciprofloxacin-inducedacute pancreatitis diagnosed based on the Naranjo algorithm.
Results: During ciprofloxacin therapy, seven of 227patients (3.1%) developed rare pancreatitis as defined bythe Naranjo algorithm; pancreatic enzyme activity was sporadicallyelevated with ciprofloxacin use. After ciprofloxacinadministration, the average interval until the development ofpancreatitis was 5.5 days (range, 4 to 7 days). On abdominalcomputed tomography, pancreatic swelling and homogenousenhancement was noted in three of seven patients. Complicatingacute pancreatitis was gradually but completelyresolved after cessation of ciprofloxacin administration. Themean recovery time was 11.3 days (range, 8 to 15 days).
Conclusions: We observed that ciprofloxacin-induced pancreatitismay occur with an incidence of approximately 3%.
Ciprofloxacin-induced pancreatitis presents a short latency,suggesting an idiosyncratic hypersensitivity reaction. Practitionersshould be aware that drug-induced pancreatitis canoccur during ciprofloxacin therapy.
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참고문헌 (17)
참고문헌 신청
Adam U / 2001 / The penetration of ciprofloxacin into human pancreatic and peripancreatic necroses in acute necrotizing pancreatitis / Infection 29 : 326 ~ 331
Ball P / 1995 / Tolerability of fluoroquinolone antibiotics: past, present and future / Drug Saf 13 : 343 ~ 358
Cinar E / 2003 / Is late antibiotic prophylaxis effective in the prevention of secondary pancreatic infection? / Pancreatology 3 : 383 ~ 388
Ericsson CD / 1987 / Ciprofloxacin or trimethoprim-sulfamethoxazole as initial therapy for travelers’ diarrhea: a placebo-controlled, randomized trial / Ann Intern Med 106 :
Garcia-Barrasa A / 2009 / A double-blind, placebo-controlled trial of ciprofloxacin prophylaxis in patients with acute necrotizing pancreatitis / J Gastrointest Surg 13 : 76
Ball P / 1995 / Tolerability of fluoroquinolone antibiotics: past, present and future / Drug Saf 13 : 343 ~ 358
Cinar E / 2003 / Is late antibiotic prophylaxis effective in the prevention of secondary pancreatic infection? / Pancreatology 3 : 383 ~ 388
Ericsson CD / 1987 / Ciprofloxacin or trimethoprim-sulfamethoxazole as initial therapy for travelers’ diarrhea: a placebo-controlled, randomized trial / Ann Intern Med 106 :
Garcia-Barrasa A / 2009 / A double-blind, placebo-controlled trial of ciprofloxacin prophylaxis in patients with acute necrotizing pancreatitis / J Gastrointest Surg 13 : 76
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