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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 275 - 282 (8page)
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Background/Aims: To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). Methods: Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from November 2010 to March 2013 were prospectively recruited from three tertiary hospitals. Results: We analyzed 105 patients (median age of 47 years). The F0–1, F2, F3, and F4 fibrosis stages were identified in 27 (25.7%), 27 (25.7%), 21 (20.0%), and 30 (28.6%) patients, respectively.
The areas under the receiver operating characteristics curves for ARFI elastography in assessing ≥F2, ≥F3, and F4 was 0.814, 0.848, and 0.752, respectively. The discordance of at least one stage between LB and ARFI was observed in 68 patients (64.8%) and of at least two stages in 16 patients (15.2%). In a multivariate analysis, advanced fibrosis stage (F3–4) was the only factor that was negatively correlated with one-stage discordance (p=0.042). Moreover, advanced fibrosis stage was negatively (p=0.016) correlated and body mass index (BMI) was positively (p=0.006) correlated with two-stage discordance. Conclusions: Advanced fibrosis stage (F3–4) was a predictor of nondiscordance between LB and ARFI elastography; BMI also influenced the accuracy of ARFI elastography.
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참고문헌 (35)
참고문헌 신청
Keeffe EB / 2008 / A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update / Clin Gastroenterol Hepatol 6:1315~1341
Bravo AA / 2001 / Liver biopsy / N Engl J Med 344:495~500
Bedossa P / 2003 / Sampling variability of liver fibrosis in chronic hepatitis C / Hepatology 38:1449~1457
Poynard T / 2007 / Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation / Aliment Pharmacol Ther 25:733~739
Rousselet MC / 2005 / Sources of variability in histological scoring of chronic viral hepatitis / Hepatology 41:257~264
Bravo AA / 2001 / Liver biopsy / N Engl J Med 344:495~500
Bedossa P / 2003 / Sampling variability of liver fibrosis in chronic hepatitis C / Hepatology 38:1449~1457
Poynard T / 2007 / Variability of the area under the receiver operating characteristic curves in the diagnostic evaluation of liver fibrosis markers: impact of biopsy length and fragmentation / Aliment Pharmacol Ther 25:733~739
Rousselet MC / 2005 / Sources of variability in histological scoring of chronic viral hepatitis / Hepatology 41:257~264
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