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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 94 - 101 (8page)
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Background/Aims: In addition to the globally endorsed Barcelona Clinic Liver Cancer (BCLC) staging system, other algorithms or staging systems have been developed, including the Hong Kong Liver Cancer (HKLC) staging system. This study aimed to validate the HKLC staging system relative to the BCLC staging system for predicting survival for hepatocellular carcinoma (HCC) patients in Korea. Methods: From 2004 to 2013, 2,571 patients newly diagnosed with HCC were consecutively enrolled at three Korea University medical centers. Results: Both staging systems differentiated survival well (p<0.001). However, 1-year and 3-year survival were predicted better using the HKLC system than the BCLC system (area under the receiver operating characteristic curve: 0.869 vs 0.856 for 1 year, p=0.002; 0.841 vs 0.827 for 3 years, p=0.010). In hypothetical survival curves, the HKLC system exhibited better median overall survival than the BCLC system (33.1 months vs 19.2 months). In evaluations of prognosis according to either BCLC or HKLC treatment guidelines, risk of death was reduced in the group following only HKLC guidelines compared with the group following only BCLC guidelines (hazard ratio, 0.601; 95% confidence interval, 0.443 to 0.816; p=0.001). Conclusions: Although both staging systems predicted and discriminated HCC prognoses well, the HKLC system showed more encouraging survival benefits than the BCLC system.
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참고문헌 (24)
참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Meier V / 2009 / Clinical staging of hepatocellular carcinoma / Dig Dis 27:131~141
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17:1471~1474
Yau T / 2014 / Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma / Gastroenterology 146:1691~1700
Sanyal AJ / 2010 / The etiology of hepatocellular carcinoma and consequences for treatment / Oncologist 15(Suppl 4):14~22
Meier V / 2009 / Clinical staging of hepatocellular carcinoma / Dig Dis 27:131~141
Edge SB / 2010 / The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17:1471~1474
Yau T / 2014 / Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma / Gastroenterology 146:1691~1700
Sanyal AJ / 2010 / The etiology of hepatocellular carcinoma and consequences for treatment / Oncologist 15(Suppl 4):14~22
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