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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 79 - 85 (7page)
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초록· 키워드
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Background/Aims: The annual risk of transformation of non-hypervascular magnetic resonance (MR) hepatobiliary phase imaging (HBPI) hypointense nodules into hypervascular hepatocellular carcinomas (HCCs) was evaluated. Methods: Cirrhotic patients with non-hypervascular HBPI hypointense nodules were retrospectively analyzed if they were diagnosed as HCC and MR followed up longer than 1 year during the period from January 2010 to October 2016 with regular intervals of 3 to 6 months. Risk factors for transformation into hypervascular HCCs were analyzed using the Cox proportional hazard model. Results: Among the 103 non-hypervascular HBPI hypointense nodules meeting the inclusion criteria, transformation into hypervascular HCCs occurred in 44 tumors (42.7%). The median follow-up period was 24 months. Multivariate analysis revealed that hyperintensity on T2-weighted images (T2WI) and diffusion-weighted images (DWI) were the two independent predictors of transformation into hypervascular HCCs (p=0.036 and p=0.041, respectively). Most tumors with hyperintensity on T2WI or DWI on the initial or follow-up MR were transformed into hypervascular HCCs within the first year. Among the 22 nodules (21.3%) showing a new change in dynamic phases during follow-up, 14 nodules (13.6%) showed malignant transformations. Conclusions: The transformation rates of HBPI hypointense nodules into hypervascular HCCs could be predicted according to the initial or serial MRI findings.
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참고문헌 (21)
참고문헌 신청
Takayama T / 1990 / Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma / Lancet 336:1150~1153
Kitao A / 2009 / Hepatocarcinogenesis: multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography--radiologic-pathologic correlation / Radiology 252:605~614
El-Serag HB / 1999 / Rising incidence of hepatocellular carcinoma in the United States / N Engl J Med 340:745~750
Choi BI / 2015 / Diagnosing borderline hepatic nodules in hepatocarcinogenesis: imaging performance / AJR Am J Roentgenol 205:10~21
Nakashima O / 1995 / Pathomorphologic characteristics of small hepatocellular carcinoma: a special reference to small hepatocellular carcinoma with indistinct margins / Hepatology 22:101~105
Kitao A / 2009 / Hepatocarcinogenesis: multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography--radiologic-pathologic correlation / Radiology 252:605~614
El-Serag HB / 1999 / Rising incidence of hepatocellular carcinoma in the United States / N Engl J Med 340:745~750
Choi BI / 2015 / Diagnosing borderline hepatic nodules in hepatocarcinogenesis: imaging performance / AJR Am J Roentgenol 205:10~21
Nakashima O / 1995 / Pathomorphologic characteristics of small hepatocellular carcinoma: a special reference to small hepatocellular carcinoma with indistinct margins / Hepatology 22:101~105
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