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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 216 - 225 (10page)
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초록· 키워드
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Background/Aims: Patients with active ulcerative colitis (UC) have elevated levels of activated myeloid-derived leukocytes as a source of inflammatory cytokines. The selective depletion of these leukocytes by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn should alleviate inflammation, promote remission and enhance drug efficacy.
However, studies have reported contrasting efficacy outcomes based on patients’ baseline demographic variables.
This study was undertaken to understand the demographic features of GMA responders and nonresponders. Methods: This was a multicenter study in China involving four institutions and 34 patients with active UC. Baseline conventional medications were continued without changing the dosage.
The treatment efficacy was evaluated based on the endoscopic activity index and the Mayo score. Results: Thirty of the 34 patients completed all 10 GMA treatment sessions.
The overall efficacy rate was 70.59%. The receiver operating characteristic analysis showed that the area under the curve was approximately 0.766 for a Mayo score of ≤5.5 with 0.273 specificity and 0.857 sensitivity (Youden index, 0.584) for GMA responders. No GMA-related serious adverse events were observed. Conclusions: The overall efficacy of GMA in patients with active UC who were taking first-line medications or were corticosteroid refractory was encouraging. Additionally, GMA was well tolerated and had a good safety profile.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Conrad K / 2014 / Diagnosis and classification of ulcerative colitis / Autoimmun Rev 13 : 463 ~ 466
Inoue T / 2013 / The efficacy of oral tacrolimus in patients with moderate/severe ulcerative colitis not receiving concomitant corticosteroid therapy / Intern Med 52 : 15 ~
Isomoto H / 2013 / Magnifying endoscopic findings can predict clinical outcome during long-term follow-up of more than 12 months in patients with ulcerative colitis / Gastro
Ken Fukunaga / 2012 / Adsorptive Granulocyte/Monocyte Apheresis for the Maintenance of Remission in Patients with Ulcerative Colitis: A Prospective Randomized, Double Blind,
Noguchi A / 2007 / The production of interferon-gamma-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity / J Gastroent
Inoue T / 2013 / The efficacy of oral tacrolimus in patients with moderate/severe ulcerative colitis not receiving concomitant corticosteroid therapy / Intern Med 52 : 15 ~
Isomoto H / 2013 / Magnifying endoscopic findings can predict clinical outcome during long-term follow-up of more than 12 months in patients with ulcerative colitis / Gastro
Ken Fukunaga / 2012 / Adsorptive Granulocyte/Monocyte Apheresis for the Maintenance of Remission in Patients with Ulcerative Colitis: A Prospective Randomized, Double Blind,
Noguchi A / 2007 / The production of interferon-gamma-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity / J Gastroent
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