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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 100 - 106 (7page)
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초록· 키워드
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Purpose: Beta blocker (BB) has been prescribed for anxiety and panic disorder. Patients intoxicated by psychiatric drugs have often been exposed to BB. Moreover, BB overdose has adverse effects including cardiovascular effects, which can be life-threatening. This study was conducted to identify the characteristics of BB intoxication with psychiatric drugs and the adverse effects on the cardiovascular system.
Methods: A single center, retrospective study was performed from January 2010 to December 2015. A total of 4,192 patients visited the emergency department (ED) with intoxication, and 69 with BB intoxication were enrolled.
Results: Overall, 64 patients (92.8%) of enrolled patients were intoxicated with drugs prescribed for the purpose of psychiatric disorders. Propranolol was the most common BB (62 cases, 96.2%), and the median dose was 140.0 mg (25%-75% 80.0-260.0). Twenty-four patients (37.5%) had experienced cardiovascular events, and these patients tended to have decreased mentality, hypotension and coingestion with quetiapine. An initial mean arterial pressure (MAP) below 65 mmHg (odds ratio 10.069, 95% confidence interval 1.572-64.481, p=0.015) was identified as a factor of cardiovascular event upon multiple logistic regression analysis.
Conclusion: Initial MAP below 65 mmHg was a factor of cardiovascular adverse effect in patients of BB intoxication with psychiatric drugs.
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참고문헌 (19)
참고문헌 신청
Graudins A / 2016 / Calcium channel antagonist and beta-blocker overdose: antidotes and adjunct therapies / Br J Clin Pharmacol 81:453~461
DeWitt CR / 2004 / Pharmacology, pathophysiology and management of calcium channel blocker and betablocker toxicity / Toxicol Rev 23:223~238
Mowry JB / 2014 / 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 31st Annual Report / J Toxicol Clin Toxicol 52:1032~1283
Love JN / 2000 / Acute beta blocker overdose: factors associated with the development of cardiovascular morbidity / J Toxicol Clin Toxicol 38:275~281
Sadock BJ / 2014 / Kaplan and Sadock’s synopsis of psychiatry: Behavioral sciences/clinical psychiatry / Lippincott Williams & Wilkins :933~935
DeWitt CR / 2004 / Pharmacology, pathophysiology and management of calcium channel blocker and betablocker toxicity / Toxicol Rev 23:223~238
Mowry JB / 2014 / 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 31st Annual Report / J Toxicol Clin Toxicol 52:1032~1283
Love JN / 2000 / Acute beta blocker overdose: factors associated with the development of cardiovascular morbidity / J Toxicol Clin Toxicol 38:275~281
Sadock BJ / 2014 / Kaplan and Sadock’s synopsis of psychiatry: Behavioral sciences/clinical psychiatry / Lippincott Williams & Wilkins :933~935
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