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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 13 (13page)
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Objective: The impact of beta blockers (BBs) on survival outcomes in ovarian cancer was investigated. Methods: By using Korean National Health Insurance Service Data, Cox proportional hazards regression was performed to analyze hazard ratios (HRs) with 95% confidence intervals (CIs) adjusting for confounding factors. Results: Among 866 eligible patients, 206 (23.8%) were BB users and 660 (76.2%) were non-users. Among the 206 BB users, 151 (73.3%) were non-selective beta blocker (NSBB) users and 105 (51.0%) were selective beta blocker (SBB) users. BB use in patients aged ≥60 years, longer duration use (≥1 year), in patients with Charlson Comorbidity Index (CCI) ≥3, and in cardiovascular disease including hypertension was associated with better survival outcome. These findings were observed in both NSBB and SBB. When duration of medication was analyzed based on number of days, NSBB (≥180 days) was associated with improved overall survival (OS) with a relatively shorter period of use compared to SBB (≥720 days). In multivariate Cox proportional hazards model, longer duration of BB medication (≥1 year) was an independent favorable prognostic factor for both OS and disease-specific survival in ovarian cancer patients. Conclusion: In our nationwide population-based cohort study, BB use was associated with better survival outcomes in ovarian cancer in cases of long term duration of use, in older patients, and in cardiovascular and/or other underlying disease (CCI ≥3).
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참고문헌 (26)
참고문헌 신청
Siegel RL / 2017 / Cancer statistics, 2017 / CA Cancer J Clin 67:7~30
정규원 / 2017 / Prediction of Cancer Incidence and Mortality in Korea, 2017 / Cancer Research and Treatment 49(2):306~312
임명철 / 2013 / Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010 / Journal of Gynecologic Oncology 24(4):298~302
Burger RA / 2011 / Incorporation of bevacizumab in the primary treatment of ovarian cancer / N Engl J Med 365:2473~2483
du Bois A / 2009 / Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO) / Cancer 115:1234~1244
정규원 / 2017 / Prediction of Cancer Incidence and Mortality in Korea, 2017 / Cancer Research and Treatment 49(2):306~312
임명철 / 2013 / Incidence of cervical, endometrial, and ovarian cancer in Korea, 1999-2010 / Journal of Gynecologic Oncology 24(4):298~302
Burger RA / 2011 / Incorporation of bevacizumab in the primary treatment of ovarian cancer / N Engl J Med 365:2473~2483
du Bois A / 2009 / Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO) / Cancer 115:1234~1244
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