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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: Intravenous lipid emulsion (ILE) has been shown to have significant therapeutic effects on calcium channel blocker overdose in animal studies and clinical cases. In this preliminary experiment, we investigated the hemodynamic changes and survival in a rat model of verapamil intoxication. Methods: Fourteen male Sprague-Dawley rats were sedated and treated with ILE or normal saline (control), followed by continuous intravenous infusion of verapamil (20 mg/kg/h). Mean arterial pressure and heart rate of rats were monitored during the infusion. In addition, the total dose of infused verapamil and the duration of survival were measured. Results: Survival was prolonged in the ILE group (32.43±5.8 min) relative to the control group (24.14±4.3 min) (p=0.01). The cumulative mean lethal dose of verapamil was higher in the ILE group (4.3±0.7 mg/kg) than in the control group (3.2±0.5 mg/kg; p=0.017). Conclusion: ILE pretreatment prolonged survival and increased the lethal dose in a rat model of verapamil poisoning.
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참고문헌 (27)
참고문헌 신청
Mowry JB / 2013 / 2012 annual report of the American Association Of Poison Control Centers' National Poison Data System (NPDS): 30th annual report / Clin Toxicol (Phila) 51:949~1229
Shepherd G / 2006 / Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers / Am J Health Syst Pharm 63:1828~1835
Jamaty C / 2010 / Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies / Clin Toxicol (Phila) 48:1~27
St-Onge M / 2014 / Treatment for calcium channel blocker poisoning: A systemic review / Clin Toxicol. (Phila) 52:926~944
Rosenblatt MA / 2006 / Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest / Anesthesiology 105:217~218
Shepherd G / 2006 / Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers / Am J Health Syst Pharm 63:1828~1835
Jamaty C / 2010 / Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies / Clin Toxicol (Phila) 48:1~27
St-Onge M / 2014 / Treatment for calcium channel blocker poisoning: A systemic review / Clin Toxicol. (Phila) 52:926~944
Rosenblatt MA / 2006 / Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest / Anesthesiology 105:217~218
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