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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 51 - 57 (7page)
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Purpose : Whole blood interferon-γ assay was developed and many studies showed its
usefulness in diagnosing tuberculosis (TB) including latent tuberculosis infection (LTBI).
However, assessment in children has been limited. This study was undertaken to evaluate
the usefulness of QuantiFERON-TB Gold for the diagnosis of LTBI in children exposed to
pulmonary TB.
Methods : Children who visited Seoul National University Bundang Hospital with a history
of TB exposure were enrolled from January 2006 to December 2007. They were evaluated
with chest x-rays, tuberculin skin test (TST) and QuantiFERON-TB Gold test. TST was
retested 3 months later for those with initial negative reactivity. Definition of LTBI was
made on the basis of the TST reactivity.
Results : Among the 103 children with a history of TB exposure, 49 children were tested
with chest x-ray, TST, and QuantiFERON-TB Gold. Twenty-two were males. Median age
was 7.5 years (range; 3 months to 14.7 years). According to TST reactivity, LTBI was in 8
(19%), no infection was in 21 (50%), possible LTBI was in 13 (31%). QuantiFERON-TB Gold
test was positive in 5 of the 49 subjects (10%); 3 of the 13 subjects (23.1%) in unknown status,
1 of the 8 subjects (13%) in LTBI, and 1 of the 21 subjects (5%) without infection. The
agreement between the QuantiFERON-TB Gold and the TST was poor (κ=0.101).
Conclus ion : QuantiFERON-TB Gold showed poor sensitivity for the diagnosis of LTBI in
children with exposure to TB. QuantiFERON-TB Gold alone does not seem to be useful in
the diagnosis of LTBI in children. (Korean J Pediatr Infect Dis 2008;15:50-57)
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Brock I / 2004 / Comparison of tuberculin skin test and new specific blood test in tuberculosis contacts / Am J Respir Crit Med 170 : 65 ~ 69
Connell T / 2006 / Early detection of perinatal tuberculosis using a whole blood interferon-gamma release assay / Clin Infect Dis 42 : 82 ~ 85
Connell TG / 2006 / Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in children / Thorax 61 : 616 ~ 620
Davies PDO / 2006 / The use of interferon-gamma-based blood tests for the detection of latent tuberculosis infection / Eur Respir J 28 : 1 ~ 3
Eum SY / 2008 / Evaluation of diagnostic utility of a whole-blood interferon-γ assay for determining the risk of exposure to Mycobacterium tuberculosis in Bacille Calmette-
Connell T / 2006 / Early detection of perinatal tuberculosis using a whole blood interferon-gamma release assay / Clin Infect Dis 42 : 82 ~ 85
Connell TG / 2006 / Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in children / Thorax 61 : 616 ~ 620
Davies PDO / 2006 / The use of interferon-gamma-based blood tests for the detection of latent tuberculosis infection / Eur Respir J 28 : 1 ~ 3
Eum SY / 2008 / Evaluation of diagnostic utility of a whole-blood interferon-γ assay for determining the risk of exposure to Mycobacterium tuberculosis in Bacille Calmette-
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