지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 103 - 110 (8page)
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초록· 키워드
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Purpose: The purpose of this study is to evaluate the effectiveness and the adverse events of high dose insulin/euglycemia therapy in acute calcium channel blocker (CCB) poisoning.
Methods: We developed a systematic search strategy and applied it to 4 electronic reference databases. We searched medical journals as well as the bibliographies of relevant articles. All forms of literature relevant to human use of high dose insulin for acute CCB poisoning were included. The literature search was conducted by two investigators in August, 2015 with publication language restricted to English and Korean. Case reports were divided between CCB overdose alone and multi-drug overdose including CCB. The effect and adverse event of high dose insulin and clinical outcome of each case were analyzed.
Results: Among 55 searched studies, 20 studies were included. A prospective study, a retrospective study, a systematic review study, and 17 case reports were identified. Case reports consisted of 11 CCB alone and 12 multidrug overdose cases including CCB. Although most cases described significant clinical improvements, one of them showed no beneficial effect. Several adverse events including hypoglycemia and hypokalemia were reported. No significant sequalae from adverse events was reported.
Conclusion: Although there were many case reports demonstrating successful use of high dose insulin for CCB poisoning, the effect cannot be estimated due to a possibility of publication bias. Therefore, high dose insulin/euglycemia therapy might be considered adjunctive therapy in cases of CCB intoxication refractory for standard therapy.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Mowry JB / 2014 / 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System(NPDS) : 31st Annual Report / Clin Toxicol(Phila) 52:1032~1283
Lheureux PE / 2006 / Bench-to-bedside review : hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers / Crit Care 10:212
Yuan TH / 1999 / Insulin-glucose as adjunctive therapy for severe calcium channel antagonist poisoning / J Toxicol Clin Toxicol 37:463~474
Marques M / 2003 / Treatment of calcium channel blocker intoxication with insulin infusion : case report and literature review / Resuscitation 57:211~213
Harris NS / 2006 / Case records of the Massachusetts General Hospital. Case 24-2006. A 40-year-old woman with hypotension after an overdose of amlodipine / N Engl J Med 355:602~611
Lheureux PE / 2006 / Bench-to-bedside review : hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers / Crit Care 10:212
Yuan TH / 1999 / Insulin-glucose as adjunctive therapy for severe calcium channel antagonist poisoning / J Toxicol Clin Toxicol 37:463~474
Marques M / 2003 / Treatment of calcium channel blocker intoxication with insulin infusion : case report and literature review / Resuscitation 57:211~213
Harris NS / 2006 / Case records of the Massachusetts General Hospital. Case 24-2006. A 40-year-old woman with hypotension after an overdose of amlodipine / N Engl J Med 355:602~611
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