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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Although nuclear factor of activated T cell (NFAT) plays a key role in inflammation, its anti-inflammatory effects and mechanism of action in periodontitis are still unknown. This study aimed to identify the effects of NFAT on the proinflammatory mediators activated by lipopolysaccharide (LPS) plus nicotine stimulation in human periodontal ligament cells (hPDLCs). The production of nitric oxide (NO) and prostaglandin E2 (PGE2) was evaluated using Griess reagent and an enzyme immunoassay, respectively. The expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and NFAT proteins was evaluated by Western blot analysis. LPS plus nicotine synergistically induced the production of NO and PGE2 and increased the protein expression of iNOS, COX-2 and NFAT. Treatment with an NFAT inhibitor blocked the LPS plus nicotine-stimulated NO and PGE2 release as well as the expression of iNOS and COX-2. Our data suggest that the LPS plus nicotine-induced inflammatory effects on hPDLCs may act through a novel mechanism involving the action of NFAT. Thus, NFAT may provide a potential therapeutic target for the treatment of periodontal disease associated with smoking and dental plaque.
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참고문헌 (26)
참고문헌 신청
[학술지(
Bregstrom J / 2003 / Tobacco smoking and risk of periodontal disease / J Clin Periodontol 30 : 107 ~ 113
Chang YC / 2003 / Induction of cfos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels / J Periodontal Res 38 : 44 ~ 50
Chang YC / 2003 / Induction of cyclooxygenase-2 mRNA and protein expression in human gingival fibroblasts stimulated with nicotine. / J Periodontal Res 38 : 496 ~ 501
Chang YC / 2005 / The upregulation of heme oxygenase-1 expression in human gingival fibroblasts stimulated with nicotine / J Periodontal Res 40 : 252 ~ 257
Bregstrom J / 2003 / Tobacco smoking and risk of periodontal disease / J Clin Periodontol 30 : 107 ~ 113
Chang YC / 2003 / Induction of cfos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels / J Periodontal Res 38 : 44 ~ 50
Chang YC / 2003 / Induction of cyclooxygenase-2 mRNA and protein expression in human gingival fibroblasts stimulated with nicotine. / J Periodontal Res 38 : 496 ~ 501
Chang YC / 2005 / The upregulation of heme oxygenase-1 expression in human gingival fibroblasts stimulated with nicotine / J Periodontal Res 40 : 252 ~ 257
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