지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.4
- 수록면
- 272 - 281 (10page)
이용수
초록· 키워드
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Background: Diabetic sensorineural damage is a complication of the sensory neural system, resulting from long-term hyperglycemia. Red ginseng (RG) has shown efficacy for treatment of various diseases, including diabetes mellitus; however, there is little research about its benefit for treating sensorineural damage. Therefore, we aim to evaluate RG efficacy in alloxan-induced diabetic neuromast (AIDN) zebrafish.
Methods: In this study, we developed and validated an AIDN zebrafish model. To assess RG effectiveness, we observed morphological changes in live neuromast zebrafish. Also, zebrafish has been observed to have an ultrastructure of hair-cell cilia under scanning electron microscopy. Thus, we recorded these physiological traits to assess hair cell function. Finally, we confirmed that RG promoted neuromast recovery via nerve growth factor signaling pathway markers.
Results: First, we established an AIDN zebrafish model. Using this model, we showed via live neuromast imaging that RG fostered recovery of sensorineural damage. Damaged hair cell cilia were recovered in AIDN zebrafish. Furthermore, RG rescued damaged hair cell function through cell membrane ion balance.
Conclusion: Our data suggest that RG potentially facilitates recovery in AIDN zebrafish, and its mechanism seems to be promotion of the nerve growth factor pathway through increased expression of topomyosin receptor kinase A, transient receptor potential channel vanilloid subfamily type 1, and mitogenactivated protein kinase phosphorylation.
Methods: In this study, we developed and validated an AIDN zebrafish model. To assess RG effectiveness, we observed morphological changes in live neuromast zebrafish. Also, zebrafish has been observed to have an ultrastructure of hair-cell cilia under scanning electron microscopy. Thus, we recorded these physiological traits to assess hair cell function. Finally, we confirmed that RG promoted neuromast recovery via nerve growth factor signaling pathway markers.
Results: First, we established an AIDN zebrafish model. Using this model, we showed via live neuromast imaging that RG fostered recovery of sensorineural damage. Damaged hair cell cilia were recovered in AIDN zebrafish. Furthermore, RG rescued damaged hair cell function through cell membrane ion balance.
Conclusion: Our data suggest that RG potentially facilitates recovery in AIDN zebrafish, and its mechanism seems to be promotion of the nerve growth factor pathway through increased expression of topomyosin receptor kinase A, transient receptor potential channel vanilloid subfamily type 1, and mitogenactivated protein kinase phosphorylation.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (34)
참고문헌 신청
백광수 / 2017 / Comparison of anticancer activities of Korean Red Ginseng-derived fractions / Journal of Ginseng Research 41(3):389~391
김지혜 / 2017 / Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases / Journal of Ginseng Research 41(4):435~443
Jeong-Mu Cheon / 2015 / Insulin sensitivity improvement of fermented Korean Red Ginseng (Panax ginseng) mediated by insulin resistance hallmarks in old-aged ob/ob mice / Journal of Ginseng Research 39(4):331~337
박태영 / 2017 / Effect of Korean Red Ginseng in chronic liver disease / Journal of Ginseng Research 41(4):450~455
Faucherre A / 2009 / Afferent neurons of the zebrafish lateral line are strict selectors of hair-cell orientation / PLoS One 4(2):e4477
김지혜 / 2017 / Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases / Journal of Ginseng Research 41(4):435~443
Jeong-Mu Cheon / 2015 / Insulin sensitivity improvement of fermented Korean Red Ginseng (Panax ginseng) mediated by insulin resistance hallmarks in old-aged ob/ob mice / Journal of Ginseng Research 39(4):331~337
박태영 / 2017 / Effect of Korean Red Ginseng in chronic liver disease / Journal of Ginseng Research 41(4):450~455
Faucherre A / 2009 / Afferent neurons of the zebrafish lateral line are strict selectors of hair-cell orientation / PLoS One 4(2):e4477
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