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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 42 - 56 (15page)
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Dyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated over decades, we still lack comprehensive understanding on the etiology of dyslipidemia due to the complexity and the innate multimodality of the diseases. While mouse has been the model organism of choice to investigate the pathophysiology of human dyslipidemia, zebrafish, a small freshwater fish which has traditionally used to study vertebrate development, has recently emerged as an alternative model organism. In this review, we will provide comprehensive perspective on zebrafish as a model organism for human dyslipidemia; we will discuss the attributes of zebrafish as a model, and compare the lipid metabolism in zebrafish and humans. In addition, we will summarize current landscape of zebrafish-based dyslipidemia research.
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참고문헌 (75)
참고문헌 신청
Lozano R / 2012 / Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010 : a systematic analysis for the Global Burden of Disease Study 2010 / Lancet 380:2095~2128
Phan J / 2019 / Hyperlipidemia and nonalcoholic steatohepatitis predispose to hepatocellular carcinoma development without cirrhosis / J Clin Gastroenterol 53:309~313
Ishibashi S / 1994 / The two-receptor model of lipoprotein clearance : tests of the hypothesis in"knockout"mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins / Proc Natl Acad Sci U S A 91:4431~4435
Havel RJ / 1980 / Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency / J Clin Invest 66:1351~1362
Bertolini S / 2000 / Clinical expression of familial hypercholesterolemia in clusters of mutations of the LDL receptor gene that cause a receptor-defective or receptor-negative phenotype / Arterioscler Thromb Vasc Biol 20:E41
Phan J / 2019 / Hyperlipidemia and nonalcoholic steatohepatitis predispose to hepatocellular carcinoma development without cirrhosis / J Clin Gastroenterol 53:309~313
Ishibashi S / 1994 / The two-receptor model of lipoprotein clearance : tests of the hypothesis in"knockout"mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins / Proc Natl Acad Sci U S A 91:4431~4435
Havel RJ / 1980 / Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency / J Clin Invest 66:1351~1362
Bertolini S / 2000 / Clinical expression of familial hypercholesterolemia in clusters of mutations of the LDL receptor gene that cause a receptor-defective or receptor-negative phenotype / Arterioscler Thromb Vasc Biol 20:E41
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