Effect of Citrus macroptera Fruit Pulp Juice on Alteration of Caspase Pathway Rendering Anti-Proliferative Activity against Ehrlich's Ascites Carcinoma in Mice

Md. Mahmudul Hasan; Md. Shihabul Islam; Kazi Md. Faisal Hoque; Ariful Haque; Md Abu Reza

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저자정보: Md. Mahmudul Hasan (University of Rajshahi) Md. Shihabul Islam (University of Rajshahi) Kazi Md. Faisal Hoque (University of Rajshahi) Ariful Haque (University of Rajshahi) Md Abu Reza (University of Rajshahi)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.35 No.3

발행연도: 2019.7

수록면: 271 - 277 (7page)

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Citrus macroptera (Rutaceae) has long been used in folk medicine in Bangladesh. Considering the folkloric context, this study was aimed to scrutinize anti-proliferative activity of C. macroptera fruit pulp juice (CMFPJ) against Ehrlich’s ascites carcinoma (EAC). The anti-proliferative capacity of CMFPJ was investigated and confirmed primarily using MTT assay. In vivo anti-proliferative aptitude of CMFPJ was investigated with 25, 50, and 100 mg/kg/day intraperitoneal (i.p.) treatment. Anti-proliferative efficacy of CMFPJ was assessed based on EAC growth inhibition. CMFPJ inhibited EAC growth in vitro in a dose-dependent manner. And the percentages of in vivo EAC growth inhibition were 19.53, 49.2, and 68.9% at 25, 50, and 100 mg/kg CMFPJ respectively. CMFPJ significantly induced expression of apoptosis regulatory genes caspase-8, caspase-9, cytochrome-c, and caspase-3. This considerable anti-cancer activity was perhaps due to combinatorial effect of lectin, polyphenols, and flavonoids present in CMFPJ.

#Citrus macroptera #Extrinsic pathway #Intrinsic pathway #Apoptosis

참고문헌 (25)

참고문헌 신청

Evan, G.I. / 2001 / Proliferation, cell cycle and apoptosis in cancer / Nature 411:342~348

최경철 / 2013 / Anti-cancer Effect and Underlying Mechanism(s) of Kaempferol, a Phytoestrogen, on the Regulation of Apoptosis in Diverse Cancer Cell Models / 한국독성학회지 29(4):229~234

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Thornberry, N.A. / 1998 / Caspases: enemies within / Science 281:1312~1316

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