지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 141 - 147 (7page)
- DOI
- 10.7783/KJMCS.2018.26.2.141
이용수
초록· 키워드
오류제보하기
Background: Astilbe chinensis (Maxim.) Franch. Et Savat. is a plant belonging to Saxifragaceae family and contains various active ingredients including astilbin and bergenin. It has been used as a traditional Korean medicine to improve fever, pain, and cough. Recently, a number of Korean medical resources have been studied for cancer and inflammation treatment, but A. chinensis (Maxim.) Franch. Et Savat. has not yet been investigated. Consequently, this study investigated the inhibitory effect of ethanol extracts from A. chinensis (Maxim.) Franch. Et Savat. (ARE) on oxidative stress and colorectal cancer using RAW264.7 and the human colorectal cancer cell line HCT-116.
Methods and Results: In total, 500 ㎍/㎖ ARE reduced cell viability by 38.96 ± 1.32%, and increased caspase-3 activity by 133.08 ± 3.41% in HCT-116 cells. Moreover, TUNEL signaling and the early apoptosis ratio (34.56 ± 1.67%) increased by 500 ㎍/㎖ ARE treatment. H₂O₂-induced oxidative stress and cell death were diminished by 500 ㎍/㎖ ARE treatment through decreasing ROS (reactive oxygen species).
Conclusions: The inhibitory effects of ARE against human colorectal cancer cells is mediated by apoptosis and caspase-3 activation, and H₂O₂-induced ROS generation and cell death are decreased by ARE treatment in RAW264.7 cells. However, further study is required to explore how ARE treatment is involved in the signaling pathway to decrease ROS.
Methods and Results: In total, 500 ㎍/㎖ ARE reduced cell viability by 38.96 ± 1.32%, and increased caspase-3 activity by 133.08 ± 3.41% in HCT-116 cells. Moreover, TUNEL signaling and the early apoptosis ratio (34.56 ± 1.67%) increased by 500 ㎍/㎖ ARE treatment. H₂O₂-induced oxidative stress and cell death were diminished by 500 ㎍/㎖ ARE treatment through decreasing ROS (reactive oxygen species).
Conclusions: The inhibitory effects of ARE against human colorectal cancer cells is mediated by apoptosis and caspase-3 activation, and H₂O₂-induced ROS generation and cell death are decreased by ARE treatment in RAW264.7 cells. However, further study is required to explore how ARE treatment is involved in the signaling pathway to decrease ROS.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (21)
참고문헌 신청
Brieger K / 2012 / Reactive oxygen species: From health to disease / Swiss Medical Weekly 142:w13659
Jin-Hyuk Choi / 2007 / Bax Protein in Cancer Treatment / Journal of the Korean Medical Association 50(11):1016
Disibio G / 2008 / Metastatic patterns of cancers: Results from a large autopsy study / Archives of Pathology and Laboratory Medicine 132:931~939
Eruslanov E / 2010 / Identification of ROS using oxidized DCFDA and flow-cytometry / Advanced Protocols in Oxidative Stress II 594:57~72
Han B / 2015 / Small-molecule Bcl2 BH4 antagonist for lung cancer therapy / Cancer Cell 27:852~863
Jin-Hyuk Choi / 2007 / Bax Protein in Cancer Treatment / Journal of the Korean Medical Association 50(11):1016
Disibio G / 2008 / Metastatic patterns of cancers: Results from a large autopsy study / Archives of Pathology and Laboratory Medicine 132:931~939
Eruslanov E / 2010 / Identification of ROS using oxidized DCFDA and flow-cytometry / Advanced Protocols in Oxidative Stress II 594:57~72
Han B / 2015 / Small-molecule Bcl2 BH4 antagonist for lung cancer therapy / Cancer Cell 27:852~863
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