A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats

Mu-Jin Lee; Ho-Kyung Jung; Ki-Ho Lee; Ji-Hun Jang; Mi-Ok Sim; Tea-Gyeong Seong; Byung-Kwan Ahn; Jin-Han Shon; Seong-Ho Ham; Hyun-Woo Cho; Yong-Min Kim; Sung-Jin Park; Ji-Young Yoon; Je-Won Ko; Jong-Choon Kim

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자료유형: 학술저널

저자정보: Mu-Jin Lee (National Development Institute of Korean Medicine) Ho-Kyung Jung (National Development Institute of Korean Medicine) Ki-Ho Lee (National Development Institute of Korean Medicine) Ji-Hun Jang (National Development Institute of Korean Medicine) Mi-Ok Sim (National Development Institute of Korean Medicine) Tea-Gyeong Seong (National Development Institute of Korean Medicine) Byung-Kwan Ahn (National Development Institute of Korean Medicine) Jin-Han Shon (National Development Institute of Korean Medicine) Seong-Ho Ham (National Development Institute of Korean Medicine) Hyun-Woo Cho (National Development Institute of Korean Medicine) Yong-Min Kim (MEDVILL) Sung-Jin Park (MEDVILL) Ji-Young Yoon (Jeonju AgroBio-Materials Institute) Je-Won Ko (Chonnam National University) Jong-Choon Kim (Chonnam National University)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.35 No.2

발행연도: 2019.4

수록면: 191 - 200 (10page)

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연구주제

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연구배경

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연구방법

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Alismatis rhizoma (AR), the dried rhizome of Alisma orientale (Sam.) Juzep, is a well-known, traditional medicine that is used for the various biological activities including as a diuretic, to lower cholesterol and as an antiinflammatory agent. The present study was carried out to investigate the potential toxicity of the Alismatis rhizoma aqueous extract (ARAE) following 90-day repeated oral administration to Sprague-Dawley rats. ARAE was administered orally to male and female rats for 90 days at 0 (control), 500, 1,000 and 2,000 ㎎/㎏/day (n = 10 for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 28-day recovery period. Chromatograms of ARAE detected main compounds with four peaks. Treatment-related effects including an increase in the red blood cells, hemoglobin, hematocrit, albumin, total protein, and urine volume were observed in males of the 2,000 ㎎/㎏/day group (p ＜ 0.05). However, the diuretic effect of ARAE was considered, a major cause of hematological and serum biochemical changes. The oral noobserved-adverse-effect level (NOAEL) of the ARAE was ＞ 2,000 ㎎/㎏/day in both genders, and no target organs were identified.

#Alismatis rhizome aqueous extract #Traditional medicine #Diuretic effect #Sub-chronic toxicity #NOAEL

참고문헌 (36)

참고문헌 신청

You-Jin Choi / 2011 / Effects of Medicinal herb Extracts and their Components on Steatogenic Hepatotoxicity in Sk-hep1 Cells / 한국독성학회지 27(4):211~216

이장천 / 2008 / 택사농축액이 고지방식이를 급여한 흰쥐의 지질구성 및 TBARS량에 미치는 영향 / 대한본초학회지 23(3):113~117

박종철 / 2007 / 택사 메탄올 추출물과 주성분의 항산화작용 / 생약학회지 38(4):372~375

National Institute of Medicinal Materials / 2004 / Medicinal Plants and Animals, Science and Technology / National Institute of Medicinal Materials

Tian, T. / 2014 / Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: a review / J. Ethnopharmacol 158:373~387

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