지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 211 - 216 (6page)
이용수
초록· 키워드
오류제보하기
Herbal medicines are widely used in many countries for the treatment of many diseases. Although the use of herb extracts as alternative medicine is growing, their toxicological properties have not been thoroughly investigated. In this study, we have investigated the effects of water and ethanol extracts of 18 herbs on the hepatic lipid metabolism and steatogenic hepatotoxicity. Ethanol extracts of Cirsium japonicum, Carthamus tinctorius, Rehmanniae glutinosa (preparata), Polygala tenuifolia, Foeniculum vulgare, Polygonum multiflorum, and Acorus gramineus and water extracts of Polygonum multiflorum and Rehmanniae glutinosa induced lipid accumulation in Sk-hep1 human hepatoma cells as determined by Nile red staining. These extracts increased the luciferase activity of sterol regulatory element (SRE) and decreased that of peroxisome proliferator response element (PPRE), indicating the possibilities of enhanced fatty acid synthesis and decreased fatty acid oxidation. To identify the components responsible for the fat accumulation, we tested 50 chemicals isolated from the nine herbs. Apigenin, luteolin, pectolinarin and lupeol from Cirsium japonicum, 8-methoxypsoralen and umbelliferone from Foeniculum vulgare and pomonic acid and jiocerebroside from Rehmanniae glutinosa significantly increased the accumulation of lipid droplets. These results suggest that ethanol extracts of Cirsium japonicum, Carthamus tinctorius, Rehmanniae glutinosa (preparata), Polygala tenuifolia, Foeniculum vulgare, Polygonum multiflorum, and Acorus gramineus and water extracts of Polygonum multiflorum and Rehmanniae glutinosa can cause fatty liver disease by decreasing β-oxidation of fatty acid and increasing lipogenesis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (17)
참고문헌 신청
Angulo,P / 2002 / Non-alcoholic Fatty Liver Disease / New Engl. JMed 346:1221~1231
Bellentani, S. / 2000 / Prevalence ofand risk factors for hepatic steatosis in Northern Italy / Ann.Intern. Med 132:112~117
Soo Im Choi / 2007 / Mechanism of Apoptosis Induced by Apigenin in HepG2 Human Hepatoma Cells: Involvement of Reactive Oxygen Species Generated by NADPH Oxidase / Archives of Pharmacal Research 30(10):1328~1335
Costet, P. / 1998 / Peroxisome proliferator-activated receptoralpha-isoform deficiency leads to progressive dyslipidemia withsexually dimorphic obesity and steatosis / J Biol. Chem 273:29577~29585
Deboyser, D. / 1989 / Investigation into the mechanism of tetracycline-induced steatosis:study in isolated hepatocytes / Toxicol. Appl. Pharmacol 97:473~479
Bellentani, S. / 2000 / Prevalence ofand risk factors for hepatic steatosis in Northern Italy / Ann.Intern. Med 132:112~117
Soo Im Choi / 2007 / Mechanism of Apoptosis Induced by Apigenin in HepG2 Human Hepatoma Cells: Involvement of Reactive Oxygen Species Generated by NADPH Oxidase / Archives of Pharmacal Research 30(10):1328~1335
Costet, P. / 1998 / Peroxisome proliferator-activated receptoralpha-isoform deficiency leads to progressive dyslipidemia withsexually dimorphic obesity and steatosis / J Biol. Chem 273:29577~29585
Deboyser, D. / 1989 / Investigation into the mechanism of tetracycline-induced steatosis:study in isolated hepatocytes / Toxicol. Appl. Pharmacol 97:473~479
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UCI(KEPA) : I410-ECN-0101-2013-513-001112879