지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background : Ginger has been extensively used in foods and traditional medicines in Asian countries. Despite its frequent consumption in daily life, the mechanism of potential interactions between ginger components-drug has not been examined. To elucidate the mechanism of governing the effects of 6-shogaol, a primary constituent of dried ginger, on human cytochrome P450 (CYP) isoenzymes an incubation studies were carried out using pooled human liver microsome (HLM).
Methods and Results : CYP isoenzyme specific substrate was incubated with multiple concentrations of inhibitor, HLM and cofactors. 6-shogaol showed a potent inhibitory effect on CYP2C9, CYP1A2 and CYP2C19 with half maximal inhibitory concentration (IC50) values of 29.20, 20.68 and 18.78 μM respectively. To estimate the value of the inhibition constant (K<sup>i</sup>) and the mode of inhibition, an incubation study with varying concentrations of each CYP isoenzyme-specific probe was performed. 6-shogaol inhibited CYP2C9 and CYP2C19 noncompetitively (K<sup>i</sup> = 29.02 and 19.26 μM respectively), in contrast, the inhibition of CYP1A2 was best explained by competitive inhibition (K<sup>i</sup> = 6.33 μM).
Conclusions : These findings suggest that 6-shogaol may possess inhibitory effects on metabolic activities mediated by CYP1A2, CYP2C9 and CYP2C19 in humans.
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참고문헌 (21)
참고문헌 신청
Baliga MS / 2011 / Update on the chemopreventive effects of ginger and its phytochemicals / Critical Reviews in Food Science and Nutrition 51:499~523
Cameron MD / 2005 / Cooperative binding of midazolam with testosterone and α-naphthoflavone within the CYP3A4 active site : A NMR T1paramagnetic relaxation study / Biochemistry 44:14143~14151
Court MH / 1997 / Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species / Biopharmaceutics and Drug Disposition 18:213~226
Dugasani S / 2010 / Comparative antioxidant and anti-inflammatory effects of-gingerol, -gingerol, -gingerol, and-shogaol / Journal of Ethnopharmacology 127:515~520
Ernst E / 2000 / Efficacy of ginger for nausea and vomiting : A systematic review of randomized clinical trials / British Journal of Anaesthesia 84:367~371
Cameron MD / 2005 / Cooperative binding of midazolam with testosterone and α-naphthoflavone within the CYP3A4 active site : A NMR T1paramagnetic relaxation study / Biochemistry 44:14143~14151
Court MH / 1997 / Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species / Biopharmaceutics and Drug Disposition 18:213~226
Dugasani S / 2010 / Comparative antioxidant and anti-inflammatory effects of-gingerol, -gingerol, -gingerol, and-shogaol / Journal of Ethnopharmacology 127:515~520
Ernst E / 2000 / Efficacy of ginger for nausea and vomiting : A systematic review of randomized clinical trials / British Journal of Anaesthesia 84:367~371
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UCI(KEPA) : I410-ECN-0101-2019-480-000587067