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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.10
- 수록면
- 368 - 372 (5page)
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초록· 키워드
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In this study, we investigated on antioxidative activity and nitric oxide production inhibitory activity of various solvent extracts of Lespedeza bicolor. The total polyphenol content of the methanol extract was 192.6㎎/g and flavonoid content of the acetone extract was 40.6㎎/g, as the highest content. In DPPH radical scavenging ability, SC<sub>50</sub> values of the ethanol and methanol extract were exhibited 0.69 ㎎/㎖ and 0.89 ㎎/㎖, respectively. However, in nitric oxide(NO) scavenging ability, SC<sub>50</sub> values of the acetone was exhibited 0.72 ㎎/㎖ as the highest activity. Moreover, the acetone extract showed strong NO production inhibitory effect in lipopolysaccharide(LPS)-stimulated Raw 264.7 cell. In the cytotoxicity measurement by MTT assay, the extracts were exhibited Raw 264.7 cell viabilities of 92.57~129.04% as nontoxic result in concentration of 65~650 ㎍/㎖. As a result, the acetone extract of L. bicolor could be applicable to functional materials for anti-inflammatory related fields.
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참고문헌 (29)
참고문헌 신청
Baek / 2008 / Inhibitory Effect of Dalbergioidin Isolated from the Trunk of Lespedezacyrtobotrya on Melanin Biosynthesis / Journal of Microbiology and Biotechnology 18(5):874~879
Blois MS / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181:1199~1200
Brune B / 2003 / Nitric oxide, oxidative stress and apoptosis / Kidney International Supplement 84:4~22
김상찬 / 2005 / 현삼메탄올 추출물이 LPS로 유도된Raw 264.7 cell에서의 TNF-α, IL-1β, IL-6 및 nitric oxide 생성에 미치는 영향 / 대한본초학회지 20(2):7~16
Chung HT / 2001 / Nitric oxide as a bioregulator of apoptosis / Biochemical and Biophysical Research Communications 282:1075~1079
Blois MS / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181:1199~1200
Brune B / 2003 / Nitric oxide, oxidative stress and apoptosis / Kidney International Supplement 84:4~22
김상찬 / 2005 / 현삼메탄올 추출물이 LPS로 유도된Raw 264.7 cell에서의 TNF-α, IL-1β, IL-6 및 nitric oxide 생성에 미치는 영향 / 대한본초학회지 20(2):7~16
Chung HT / 2001 / Nitric oxide as a bioregulator of apoptosis / Biochemical and Biophysical Research Communications 282:1075~1079
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UCI(KEPA) : I410-ECN-0101-2019-480-000590102