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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.3
- 수록면
- 11 - 15 (5page)
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초록· 키워드
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Purpose: The aim of this study was to compare the potency-stabilizing effects of two different diluents of botulinum toxin A (10% dextrose solution and 0.9% saline).
Methods: A mouse lethality bioassay was undertaken. Ninety mice were divided into experimental and control groups which received varying dosages in subgroups of 10. The experimental group was injected with botulinum toxin A diluted with 10% dextrose solution and the control group was injected with botulinum toxin A diluted with 0.9% saline. A 72 hours after intraperitoneal injection, the number of dead mice was counted to confirm median lethal dose (LD<SUB>50</SUB>) of each group.
Results: The value of LD<SUB>50</SUB>> in the experimental group was approximately 0.131 mL (1.31 U) and the value of LD<SUB>50</SUB> in the control group was approximately 0.107 mL (1.07 U). The potency preservation rate of the experimental group was estimated to be 93.5% and that of the control group was estimated to be 76.3%.
Conclusions: Dilution with 10% dextrose solution displayed less potency loss than 0.9% saline.
Methods: A mouse lethality bioassay was undertaken. Ninety mice were divided into experimental and control groups which received varying dosages in subgroups of 10. The experimental group was injected with botulinum toxin A diluted with 10% dextrose solution and the control group was injected with botulinum toxin A diluted with 0.9% saline. A 72 hours after intraperitoneal injection, the number of dead mice was counted to confirm median lethal dose (LD<SUB>50</SUB>) of each group.
Results: The value of LD<SUB>50</SUB>> in the experimental group was approximately 0.131 mL (1.31 U) and the value of LD<SUB>50</SUB> in the control group was approximately 0.107 mL (1.07 U). The potency preservation rate of the experimental group was estimated to be 93.5% and that of the control group was estimated to be 76.3%.
Conclusions: Dilution with 10% dextrose solution displayed less potency loss than 0.9% saline.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
Scott AB / 1981 / Botulinum toxin injection of eye muscles to correct strabismus / Trans Am Ophthalmol Soc 79:734~770
Mclellan K / 1996 / Therapeutic botulinum type A toxin: factors affecting potency / Toxicon 34:975~985
Schantz EJ / 1992 / Properties and use of botulinum toxin and other microbial neurotoxins in medicine / Microbiol Rev 56:80~99
Goodnough MC / 1992 / Stabilization of botulinum toxin type A during lyophilization / Appl Environ Microbiol 58:3426~3428
Randhawa MA / 2009 / Calculation of LD50 values from the method of Miller and Tainter, 1944 / J Ayub Med Coll Abbottabad 21:184~185
Mclellan K / 1996 / Therapeutic botulinum type A toxin: factors affecting potency / Toxicon 34:975~985
Schantz EJ / 1992 / Properties and use of botulinum toxin and other microbial neurotoxins in medicine / Microbiol Rev 56:80~99
Goodnough MC / 1992 / Stabilization of botulinum toxin type A during lyophilization / Appl Environ Microbiol 58:3426~3428
Randhawa MA / 2009 / Calculation of LD50 values from the method of Miller and Tainter, 1944 / J Ayub Med Coll Abbottabad 21:184~185
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UCI(KEPA) : I410-ECN-0101-2019-515-000540566