Tissue factor expression is associated with recurrence in patients with non-metastatic colorectal cancer

Hee Jae Jung; Hye Jin Kim; Kensuke Kaneko; Yoshihiro Kazama; Kazushige Kawai; Soichiro Ishihara; Gyu-Seog Choi

추천

검색

질문

자료유형: 학술저널

저자정보: Hee Jae Jung (Kyungpook National University) Hye Jin Kim (Kyungpook National University) Kensuke Kaneko (University of Tokyo Faculty of Medicine) Yoshihiro Kazama (University of Tokyo Faculty of Medicine) Kazushige Kawai (University of Tokyo Faculty of Medicine) Soichiro Ishihara (University of Tokyo Faculty of Medicine) Gyu-Seog Choi (Kyungpook National University)

저널정보: 대한종양외과학회 KOREAN JOURNAL OF CLINICAL ONCOLOGY Korean Journal of Clinical Oncology 제14권 제2호

발행연도: 2018.12

수록면: 128 - 134 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Previous studies have addressed the role of the hypercoagulable state in the pathogenesis of cancer progression and metastasis. In this study, we investigated the association between coagulation factors, including tissue factor (TF) expression, platelet count, and fibrinogen level, and disease recurrence in patients with non-metastatic colorectal cancer.
Methods: Patients who underwent curative resection for stage II or III colorectal cancer between 2000 and 2007 were included in this study. Data from a prospectively maintained database were retrospectively reviewed. TF expression was determined by immunohistochemistry using an anti-TF monoclonal antibody. The Kaplan-Meier method was used to estimate 5-year disease-free survival.
Results: TF was highly expressed in 257 of 297 patients (86.5%). TF expression was not significantly associated with the platelet counts (P=0.180) or fibrinogen level (P=0.281). The 5-year disease-free survival rate was lower in patients with high TF expression than in patients with low TF expression (72.3% vs. 83.9%, P=0.074). In Cox hazard analysis, high TF expression was an independent risk factor for tumor recurrence(hazard ratio [HR] 2.446; 95% confidence interval [CI], 1.054–5.674; P=0.037). Undifferentiated histologic type (HR, 2.911; 95% CI, 1.308–6.481; P=0.009), venous invasion (HR, 2.784; 95% CI, 1.431–5.417; P=0.003), and lymph node metastasis (HR, 2.497; 95% CI, 1.499–4.158; P<0.001), were also significantly associated with disease recurrence.
Conclusion: TF expression is associated with a recurrence in patients with non-metastatic colorectal cancer. However, further studies are required to clarify the underlying mechanisms relating TF expression with oncologic outcomes and its potential role as a therapeutic target.

#Colonic neoplasms #Prognosis #Survival #Immunohistochemistry

참고문헌 (30)

참고문헌 신청

[학술지(정기간행물)] - Naina HV / 2012 / Paraneoplastic thrombocytosis in ovarian cancer / N Engl J Med 366 : 1840 ~

[학술지(정기간행물)] - Wang L / 2012 / Prognostic value of TP/PD-ECGF and thrombocytosis in gastric carcinoma / Eur J Surg Oncol 38 : 568 ~ 573

[학술지(정기간행물)] - Komurcuoglu B / 2011 / Prognostic value of plasma D-dimer levels in lung carcinoma / Tumori 97 : 743 ~ 748

[학술지(정기간행물)] - Sasaki K / 2012 / Impact of preoperative thrombocytosis on the survival of patients with primary colorectal cancer / World J Surg 36 : 192 ~ 200

[학술지(정기간행물)] - Key NS / 2007 / Tissue factor; from Morawitz to microparticles / Trans Am Clin Climatol Assoc 118 : 165 ~ 173

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!