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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 8 - 11 (4page)
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초록· 키워드
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One of the major challenges in methadone maintenance therapy (MMT) for drug dependence is the physiological side effects on endocrine hormones. Because of the key role of the thyroid gland in the normal functioning of the human body and brain, this study examined the effect of MMT on thyroid function. Thyroid hormones (T3, T4, and thyroid-stimulating hormone (TSH)) were evaluated in normal and user treated with MMT who were referred to the Province Clinical & Pathology Center of Urmia, Iran. The study was conducted for three months using the Case Series method. A total of 270 samples were collected, 215 were from individuals who were not treated, whereas 55 were from men treated with methadone. Average levels of T3 and T4 in non-treated sample of men are 1.34 ± 0.02 ng/mL and 90.96 ± 1.38 ng/mL while the corresponding values for patients treated with methadone are 1.39 ± 0.04 ng/mL for T3 and 94.57 ± 2.72 ng/mL for T4. Mean TSH levels of the non-treated group and the methadone consuming group were 1.75 ± 0.08 μIU/mL and 3.17 ± 0.45 μIU/mL, respectively. These results indicate that although men treated with methadone had higher levels of T3, T4, and TSH than normal individuals, only the difference in TSH level was significant. The importance of this difference among individuals on methadone maintenance programs should be investigated in larger samples over long periods of time. Additionally, the effects of methadone treatment on women should be examined.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (13)
참고문헌 신청
Mami, S. / 2011 / Effect of opium addiction on T4, T3 and TSH in male and female rats / Scientific Journal of Ilam University of Medical Sciences 20:17~22
Bhoir, K.K. / 2009 / Effects of sub-lethal heroin administration on thyroid stimulating hormone (TSH), thyroid hormones (T3, T4) and thyroid gland of Musnorvegicus / J. Environ. Biol 30:989~994
Vescovi, P.P. / 1984 / Effect of methadone on TSH and thyroid hormone secretion / Horm. Metab. Res 16:53~54
Joseph, H. / 2000 / Methadone maintenance treatment (MMT): a review of historical and clinical issues / Mt. Sinai J. Med 67:347~367
Bell, J. / 2000 / A risk-benefit analysis of methadone maintenance treatment / Drug Safety 22:179~190
Bhoir, K.K. / 2009 / Effects of sub-lethal heroin administration on thyroid stimulating hormone (TSH), thyroid hormones (T3, T4) and thyroid gland of Musnorvegicus / J. Environ. Biol 30:989~994
Vescovi, P.P. / 1984 / Effect of methadone on TSH and thyroid hormone secretion / Horm. Metab. Res 16:53~54
Joseph, H. / 2000 / Methadone maintenance treatment (MMT): a review of historical and clinical issues / Mt. Sinai J. Med 67:347~367
Bell, J. / 2000 / A risk-benefit analysis of methadone maintenance treatment / Drug Safety 22:179~190
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UCI(KEPA) : I410-ECN-0101-2019-513-000294592