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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 135 - 141 (7page)
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초록· 키워드
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In this paper, we propose to evaluate the effect of resistin-like molecule alpha (Relmα) on the progression of anemia of inflammation. Anemia of inflammation is a common feature of inflammatory disorders, including chronic kidney disease, infections, and rheumatoid arthritis. Relmα is highly up-regulated in various inflammatory states, especially those involving asthma, intestinal inflammation, and parasitic diseases, and regulates the pathogenesis of those diseases. However, the role of Relmα in anemia of inflammation is unknown. To explore the roles of Relmα in anemia of inflammation in vivo, we generated mouse model of the disease by injecting 0.25 mg/kg lipopolysaccharides (LPS) intraperitoneally into Relmα-deficient and wild-type (WT) mice daily for 10 days. Research data was expressed as differences between LPS-treated Relmα-deficient and WT mice by a two-tailed non-parametric Mann–Whitney U-test using GraphPad Instat program. The results of the study are as follows: LPS-treated Relmα-deficient mice had significantly (p<0.05) lower hemoglobin contents, hematocrit levels and red blood cell indices including mean corpuscular volume, mean corpuscular hemoglobin than WT controls. This decrease was accompanied by significant (p<0.05) increase in total white blood cell and monocyte counts in the blood. However, there was no significant difference in mRNA levels of hepatic hepcidin and renal erythropoietin between the two animal groups. Taken together, these results indicates that Relmα deficiency exacerbates the anemia by increasing inflammation, suggesting therapeutic value of Relmα in the treatment of anemia of inflammation.
목차
Abstract
I. Introduction
II. Methodology
III. Results
IV. Discussion
IV. Conclusions
REFERENCES
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] - N. J. Kassebaum / 2014 / A systematic analysis of global anemia burden from 1990 to 2010 / Blood 123 (5) : 615 ~ 624
[학술지(정기간행물)] - Clelia Madeddu / 2018 / Pathogenesis and Treatment Options of Cancer Related Anemia: Perspective for a Targeted Mechanism-Based Approach / Frontiers in Physiology 9
[학술지(정기간행물)] - Char M. Witmer / 2013 / Hematologic Manifestations of Systemic Disease (Including Iron Deficiency, Anemia of Inflammation and DIC) / Pediatric Clinics of North America 60 (6) : 1337 ~ 1348
[학술지(정기간행물)] - Guenter Weiss / 2005 / Anemia of Chronic Disease / New England Journal of Medicine 352 (10) : 1011 ~ 1023
[학술지(정기간행물)] - Chul Soo Kim / 2006 / Anemia of Chronic Disease / Journal of the Korean Medical Association 49 (10) : 920 ~
[학술지(정기간행물)] - Clelia Madeddu / 2018 / Pathogenesis and Treatment Options of Cancer Related Anemia: Perspective for a Targeted Mechanism-Based Approach / Frontiers in Physiology 9
[학술지(정기간행물)] - Char M. Witmer / 2013 / Hematologic Manifestations of Systemic Disease (Including Iron Deficiency, Anemia of Inflammation and DIC) / Pediatric Clinics of North America 60 (6) : 1337 ~ 1348
[학술지(정기간행물)] - Guenter Weiss / 2005 / Anemia of Chronic Disease / New England Journal of Medicine 352 (10) : 1011 ~ 1023
[학술지(정기간행물)] - Chul Soo Kim / 2006 / Anemia of Chronic Disease / Journal of the Korean Medical Association 49 (10) : 920 ~
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UCI(KEPA) : I410-ECN-0101-2019-004-000122120