지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 229 - 236 (8page)
이용수
초록· 키워드
오류제보하기
Cutaneous leishmaniasis (CL) has been one of the most common parasitic diseases in Saudi Arabia. This study exhibits the clinical features, diagnosis, cytokine profile and treatment of CL patients in Al-Taif province. Ninety CL suspects at a tertiary care general hospital were enrolled in one-year study. Patients were interviewed, clinically-examined, and subjected to laboratory tests: skin scraping smear microscopy, OligoC-TesT commercial PCR (Coris BioConcept) and kinetoplast DNA (kDNA) PCR for Leishmania diagnosis. Interferon-gamma (RayBio; Human IFN-γ) and nitric oxide (NO) levels in patients’ sera were evaluated before treatment with sodium stibogluconate (pentostam) with 20-day intramuscular drug regimen. Positive rates of microscopy, commercial PCR and kDNA PCR were 74.4%, 95.5% and 100%, respectively. Patients came to hospital mostly in winter (45.0%). CL was frequently exhibited in Saudi patients (78.8%), male gender (70.7%), age <20 years (50.0%), rural-dwellers (75.5%) and patients with travel history (86.6%). Lesion was mostly single ulcer (93.3%), occurred in the face (67.7%). Upon pentostam treatment, 85.1% of ulcers showed rapid healing signs. Levels of IFN-γ and NO were significantly higher in the healing than the non-healing cases (P<0.001). The kDNA PCR proved more sensitive than microscopy and OligoC-TesT commercial PCR. Our results open perspectives for IFN-γ use as a biomarker predicting treatment response.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - Reithinger R / 2007 / Cutaneous leishmaniasis / Lancet Infect Dis 7 : 581 ~ 596
[학술지(정기간행물)] - Alvar J / 2012 / Leishmaniasis worldwide and global estimates of its incidence / PLoS One 7 : e35671 ~
[학술지(정기간행물)] - Dowlati Y / 1996 / Cutaneous leishmaniasis: clinical aspect / Clin Dermatol 14 : 425 ~ 431
[학술지(정기간행물)] - von Stebut E / 2007 / Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity / Eur J Dermatol 17 : 115 ~ 122
[학술지(정기간행물)] - Carneiro PP / 2016 / The role of nitric oxide and reactive oxygen species in the killing of Leishmania braziliensis by monocytes from patients with cutaneous leishmaniasis / PLoS One 11 : e0148084 ~
[학술지(정기간행물)] - Alvar J / 2012 / Leishmaniasis worldwide and global estimates of its incidence / PLoS One 7 : e35671 ~
[학술지(정기간행물)] - Dowlati Y / 1996 / Cutaneous leishmaniasis: clinical aspect / Clin Dermatol 14 : 425 ~ 431
[학술지(정기간행물)] - von Stebut E / 2007 / Immunology of cutaneous leishmaniasis: the role of mast cells, phagocytes and dendritic cells for protective immunity / Eur J Dermatol 17 : 115 ~ 122
[학술지(정기간행물)] - Carneiro PP / 2016 / The role of nitric oxide and reactive oxygen species in the killing of Leishmania braziliensis by monocytes from patients with cutaneous leishmaniasis / PLoS One 11 : e0148084 ~
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UCI(KEPA) : I410-ECN-0101-2018-513-003118862