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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 270 - 276 (7page)
이용수
초록· 키워드
오류제보하기
Background: Notoginsenoside Ft1 is a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultralow utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1.
Methods: Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS(UHPLC-MS/MS).
Results and conclusion: Notoginsenoside Ft1 was epimerized from notoginsenoside ST4, which was generated through cleaving the carbohydrate side chains at C-20 of notoginsenosides Fa and Fc, and vinaginsenoside R7, and further converted to other compounds via hydroxylation at C-25 or hydrolysis of the carbohydrate side chains at C-3 under the acid conditions. High temperature contributed to the hydroxylation reaction at C-25 and 25% acetic acid concentration was conducive to the preparation of notoginsenoside Ft1. C-20 epimers of notoginsenoside Ft1 and ST4 were successfully separated utilizing solvent method of acetic acid solution. The theoretical preparation yield rate of notoginsenoside Ft1 was about 1.8%, which would be beneficial to further study on its bioactivities and clinical application.
Methods: Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS(UHPLC-MS/MS).
Results and conclusion: Notoginsenoside Ft1 was epimerized from notoginsenoside ST4, which was generated through cleaving the carbohydrate side chains at C-20 of notoginsenosides Fa and Fc, and vinaginsenoside R7, and further converted to other compounds via hydroxylation at C-25 or hydrolysis of the carbohydrate side chains at C-3 under the acid conditions. High temperature contributed to the hydroxylation reaction at C-25 and 25% acetic acid concentration was conducive to the preparation of notoginsenoside Ft1. C-20 epimers of notoginsenoside Ft1 and ST4 were successfully separated utilizing solvent method of acetic acid solution. The theoretical preparation yield rate of notoginsenoside Ft1 was about 1.8%, which would be beneficial to further study on its bioactivities and clinical application.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusions
References
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - Cicero AFG / 2003 / notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet / Phytother Res 17 : 174 ~ 178
[학술지(정기간행물)] - Ng TB / 2006 / Pharmacological activity of sanchi ginseng (Panax notoginseng) / J Pharm Pharmacol 58 : 1007 ~ 1019
[학술지(정기간행물)] - Qi LW / 2011 / Isolation and analysis of ginseng: advances and challenges / Nat Prod Rep 28 : 467 ~ 495
[학술지(정기간행물)] - Yang WZ / 2014 / Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity / Phytochemistry 106 : 7 ~ 24
[학술지(정기간행물)] - Wan JB / 2006 / Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD / J Pharmaceut Biomed Anal 41 : 1596 ~ 1601
[학술지(정기간행물)] - Ng TB / 2006 / Pharmacological activity of sanchi ginseng (Panax notoginseng) / J Pharm Pharmacol 58 : 1007 ~ 1019
[학술지(정기간행물)] - Qi LW / 2011 / Isolation and analysis of ginseng: advances and challenges / Nat Prod Rep 28 : 467 ~ 495
[학술지(정기간행물)] - Yang WZ / 2014 / Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity / Phytochemistry 106 : 7 ~ 24
[학술지(정기간행물)] - Wan JB / 2006 / Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD / J Pharmaceut Biomed Anal 41 : 1596 ~ 1601
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UCI(KEPA) : I410-ECN-0101-2018-524-003161135