지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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CCN3 (also known as NOV, Nephroblastoma overexpressed) proteins are involved in various pathologies during different developmental stages. We have previously shown that intracellular levels and normal extracellular secretion of CCN3 are important for neuronal differentiation. Furthermore, we demonstrated that a single amino acid in the CCN3 TSP-1 domain is important for extracellular secretion and that palmitoylation of CCN3 is required in this process. However, the effect of abnormal CCN3 accumulation on cells remains to be studied. Here, we found mutations in the TSP-1 domain of CCN3 that led to intracellular accumulation and abnormal aggregation of CCN3. It was observed that this mutation resulted in a phenomenon similar to neurodegeneration when overexpressed in the developing mouse cortex. This mutation also confirmed the activation of apoptotic gene expression in Neuro2a cells. In addition, we confirmed the in vivo transcriptional changes induced by this mutation using microarray analysis. We observed a significant increase in the expression of Anp32a, an apoptosis-related gene. Collectively, these results indicate that a single mutation in CCN3 can lead to abnormal cell death if it shows intracellular accumulation and abnormal aggregation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Brigstock DR / 1999 / The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family / Endocrine Reviews 20 : 189 ~ 206
[학술지(정기간행물)] - Chen CC / 2009 / Functions and mechanisms of action of CCN matricellular proteins / The International Journal of Biochemistry & Cell Biology 41 : 771 ~ 783
[학술지(정기간행물)] - de Oliveira GA / 2015 / Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer / Frontiers in Oncology 5 : 97 ~
[학술지(정기간행물)] - Fong KW / 2017 / Polycomb-Mediated Disruption of an Androgen Receptor Feedback Loop Drives Castration-Resistant Prostate Cancer / Cancer Research 77 : 412 ~ 422
[학술지(정기간행물)] - Heath E / 2008 / Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene / BMC Developmental Biology 8 : 18 ~
[학술지(정기간행물)] - Chen CC / 2009 / Functions and mechanisms of action of CCN matricellular proteins / The International Journal of Biochemistry & Cell Biology 41 : 771 ~ 783
[학술지(정기간행물)] - de Oliveira GA / 2015 / Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer / Frontiers in Oncology 5 : 97 ~
[학술지(정기간행물)] - Fong KW / 2017 / Polycomb-Mediated Disruption of an Androgen Receptor Feedback Loop Drives Castration-Resistant Prostate Cancer / Cancer Research 77 : 412 ~ 422
[학술지(정기간행물)] - Heath E / 2008 / Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene / BMC Developmental Biology 8 : 18 ~
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