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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.4
- 수록면
- 287 - 293 (7page)
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Lycopene, found in tomatoes and tomato products, has antioxidant, anticancer, and anti-inflammatory effects. High-mobility-group box 1 (HMGB1) mediates the pro-inflammatory responses in several inflammatory diseases. In this study, the potential roles of lycopene in the HMGB1-mediated pro-inflammatory gene expressions in the primary human-umbilical-vein endothelial cells (HUVECs) were investigated. The data showed that HMGB1 upregulated the expressions of monocyte chemotactic protein 1 (MCP-1), interleukin-6 (IL-6), secretory phospholipase A2 (sPLA2)-IIA, and prostaglandin E2 (PGE2). Lycopene pre-incubation for 6 h decreased the HMGB1-mediated induction of MCP-1, IL-6, sPLA2-IIA, and PGE2. Further study revealed that the inhibitory effects of lycopene on the HMGB-1 induced expression of pro-inflammatory genes were mediated by the inhibition of two important inflammatory cytokines: tumor necrosis factor (TNF)-α and nuclear factor (NF)-κB. These results suggest that HMGB1 upregulated the expression of pro-inflammatory genes and lycopene inhibited HMGB-1-induced pro-inflammatory genes by inhibiting TNF-α and NF-κB. This finding will serve as an important evidence in the development of a new medicine for the treatment of inflammatory diseases.
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참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Heber D / 2002 / Overview of mechanisms of action of lycopene / Exp Biol Med (Maywood) 227 : 920 ~ 923
2. [학술지(정기간행물)] - Bae JW / 2011 / Barrier protective effects of lycopene in human endothelial cells / Inflamm Res 60 : 751 ~ 758
3. [학술지(정기간행물)] - Goodwin GH / 1973 / A new group of chromatin-associated proteins with a high content of acidic and basic amino acids / Eur J Biochem 38 : 14 ~ 19
4. [학술지(정기간행물)] - Bustin M / 1996 / High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function / Prog Nucleic Acid Res Mol Biol 54 : 35 ~ 100
5. [학술지(정기간행물)] - Boonyaratanakornkit V / 1998 / High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells / Mol Cell Biol 18 : 4471 ~ 4487
2. [학술지(정기간행물)] - Bae JW / 2011 / Barrier protective effects of lycopene in human endothelial cells / Inflamm Res 60 : 751 ~ 758
3. [학술지(정기간행물)] - Goodwin GH / 1973 / A new group of chromatin-associated proteins with a high content of acidic and basic amino acids / Eur J Biochem 38 : 14 ~ 19
4. [학술지(정기간행물)] - Bustin M / 1996 / High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function / Prog Nucleic Acid Res Mol Biol 54 : 35 ~ 100
5. [학술지(정기간행물)] - Boonyaratanakornkit V / 1998 / High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells / Mol Cell Biol 18 : 4471 ~ 4487
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UCI(KEPA) : I410-ECN-0101-2018-059-003065787