Atorvastatin: In-Vivo Synergy with Metronidazole as Anti-Blastocystis Therapy

Maha M. A. Basyoni; Shawky A. Fouad; Marwa F. Amer; Ahmed Fathy Amer; Dalia Ibrahim Ismail

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자료유형: 학술저널

저자정보: Maha M. A. Basyoni (Cairo University) Shawky A. Fouad (Cairo University) Marwa F. Amer (Cairo University) Ahmed Fathy Amer (National Research Center) Dalia Ibrahim Ismail (Cairo University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.56 No.2

발행연도: 2018.4

수록면: 105 - 112 (8page)

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Blastocystis is an enteric Straminopile in tropical, subtropical and developing countries. Metronidazole has been a chemotheraputic for blastocystosis. Failures in its regimens were reported and necessitate new studies searching for alternative therapeutic agents. Aim of current study is to investigate potential effects of Atorvastatin (AVA) compared to the conventional chemotherapeutic MTZ in experimentally Blastocystis-infected mice. Anti-Blastocystis efficacy of AVA was evaluated parasitologically, histopathologically and by transmission electron microscopy using MTZ (10 mg/kg) as a control. Therapeutic efficacy of AVA was apparently dose-dependent. Regimens of AVA (20 and 40 mg/kg) proved effective against Blastocystis infections with high reduction in Blastocystis shedding (93.4-97.9%) compared to MTZ (79.3%). The highest reductions (98.1% and 99.4%) were recorded in groups of combination treatments AVA 20-40 mg/kg and MTZ 10 mg/kg. Blastocystis was nearly eradicated by the 20th day post infection. Genotype analysis revealed that genotype I was most susceptible, genotype III was less. Histopathologic and ultrastructural studies revealed apoptotic changes in Blastocystis and significant improvement of intestinal histopathological changes more remarkable in combinational therapy groups. Thus, the present study offers AVA as a potential candidate for Blastocystis therapy combined with MTZ.

#Blastocystis #atorvastatin #metronidazole #efficacy #mouse

참고문헌 (40)

참고문헌 신청

Tan KS / 2008 / New insights on classification, identification, and clinical relevance of Blastocystis spp / Clin Microbiol Rev 21:639~665

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