지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 62 - 76 (15page)
이용수
초록· 키워드
오류제보하기
Objectives: The molecular mechanisms underlying attention-deficit hyperactivity disorder (ADHD) remain unclear. Therefore, this study aimed to identify the genetic susceptibility loci for ADHD in Korean children with ADHD. We performed a case-control and a family-based genome-wide association study (GWAS), as well as genome-wide quantitative trait locus (QTL) analyses, for two symptom traits.
Methods: A total of 135 subjects (71 cases and 64 controls), for the case-control analysis, and 54 subjects (27 probands and 27 unaffected siblings), for the family-based analysis, were included.
Results: The genome-wide QTL analysis identified four single nucleotide polymorphisms (SNPs) (rs7684645 near APELA, rs12538843 near YAE1D1 and POU6F2, rs11074258 near MCTP2, and rs34396552 near CIDEA) that were significantly associated with the number of inattention symptoms in ADHD. These SNPs showed possible association with ADHD in the family-based GWAS, and with hyperactivity-impulsivity in genome-wide QTL analyses. Moreover, association signals in the family-based QTL analysis for the number of inattention symptoms were clustered near genes IL10, IL19, SCL5A9, and SKINTL.
Conclusion: We have identified four QTLs with genome-wide significance and several promising candidates that could potentially be associated with ADHD (CXCR4, UPF1, SETD5, NALCN-AS1, ERC1, SOX2-OT, FGFR2, ANO4, and TBL1XR1). Further replication studies with larger sample sizes are needed.
Methods: A total of 135 subjects (71 cases and 64 controls), for the case-control analysis, and 54 subjects (27 probands and 27 unaffected siblings), for the family-based analysis, were included.
Results: The genome-wide QTL analysis identified four single nucleotide polymorphisms (SNPs) (rs7684645 near APELA, rs12538843 near YAE1D1 and POU6F2, rs11074258 near MCTP2, and rs34396552 near CIDEA) that were significantly associated with the number of inattention symptoms in ADHD. These SNPs showed possible association with ADHD in the family-based GWAS, and with hyperactivity-impulsivity in genome-wide QTL analyses. Moreover, association signals in the family-based QTL analysis for the number of inattention symptoms were clustered near genes IL10, IL19, SCL5A9, and SKINTL.
Conclusion: We have identified four QTLs with genome-wide significance and several promising candidates that could potentially be associated with ADHD (CXCR4, UPF1, SETD5, NALCN-AS1, ERC1, SOX2-OT, FGFR2, ANO4, and TBL1XR1). Further replication studies with larger sample sizes are needed.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Polanczyk G / 2007 / The worldwide prevalence of ADHD: a systematic review and metaregression analysis / Am J Psychiatry 164 : 942 ~ 948
[학술지(정기간행물)] - Mannuzza S / 1993 / Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status / Arch Gen Psychiatry 50 : 565 ~ 576
[학술지(정기간행물)] - Faraone SV / 2005 / Molecular genetics of attention-deficit/hyperactivity disorder / Biol Psychiatry 57 : 1313 ~ 1323
[학술지(정기간행물)] - Hawi Z / 2015 / The molecular genetic architecture of attention deficit hyperactivity disorder / Mol Psychiatry 20 : 289 ~ 297
[학술지(정기간행물)] - Gizer IR / 2009 / Candidate gene studies of ADHD: a meta-analytic review / Hum Genet 126 : 51 ~ 90
[학술지(정기간행물)] - Mannuzza S / 1993 / Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status / Arch Gen Psychiatry 50 : 565 ~ 576
[학술지(정기간행물)] - Faraone SV / 2005 / Molecular genetics of attention-deficit/hyperactivity disorder / Biol Psychiatry 57 : 1313 ~ 1323
[학술지(정기간행물)] - Hawi Z / 2015 / The molecular genetic architecture of attention deficit hyperactivity disorder / Mol Psychiatry 20 : 289 ~ 297
[학술지(정기간행물)] - Gizer IR / 2009 / Candidate gene studies of ADHD: a meta-analytic review / Hum Genet 126 : 51 ~ 90
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Development of the Attention-Deficit Hyperactivity Disorder-After School Checklist
소아청소년정신의학
2018 .04
-
전문가 설문을 통한 주의력결핍 과잉행동장애 변증의 주요 증상 빈도 연구
대한한방소아과학회지
2019 .01
-
Association of Hair Manganese Level with Symptoms in Attention-Deficit/Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2015 .01
-
주의력결핍 과잉행동장애 한국형 치료 권고안 개정안(Ⅱ) : 진단 및 평가
소아청소년정신의학
2017 .04
-
주의력결핍 과잉행동장애 진단 및 치료 : ADHD 중개연구센터 가이드라인
소아청소년정신의학
2016 .12
-
The Relationship between Second-to-Fourth Digit Ratios, Attention-Deficit/Hyperactivity Disorder Symptoms, Aggression, and Intelligence Levels in Boys with Attention-Deficit/Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2020 .01
-
주의력결핍-과잉행동장애 초등학생에서 불안증상이 아동의 행동 및 주의력과 가지는 관련성에 관한 연구
대한불안의학회지
2019 .01
-
우울감을 주소로 내원한 환자들에서 주의력 결핍/과잉행동장애 증상의 공존율 분석
정신신체의학
2019 .01
-
주의력결핍 과잉행동장애 한국형 치료 권고안 개정안(Ⅰ) : 서론, 임상양상 및 공존질환
소아청소년정신의학
2017 .04
-
ADHD 및 성인 ADHD에 대한 개념적 고찰 (1): ADHD 진단의 변천-DSM을 중심으로
신경정신의학
2022 .02
-
ADHD 및 성인 ADHD에 대한 개념적 고찰 (2): ADHD의 정신병리와 진단 및 치료의 함의
신경정신의학
2022 .05
-
A Community - based Case - Control Study on Iron deficiency and Attention-Deficit Hyperactivity Disorder (ADHD) in Children
환경독성보건학회 심포지엄 및 학술대회
2015 .06
-
성인 주의력결핍과잉행동장애의 약물치료
대한의사협회지
2021 .01
-
Screening for Attention Deficit Hyperactivity Disorder among Korean College Students: Prevalence, Correlates and Comorbidities
우울조울병
2019 .01
-
Differences in Resting-state Quantitative Electroencephalography Patterns in Attention Deficit/Hyperactivity Disorder with or without Comorbid Symptoms
Clinical Psychopharmacology and Neuroscience
2017 .01
-
Sleep Problems as Predictors in Attention-Deficit Hyperactivity Disorder: Causal Mechanisms, Consequences and Treatment
Clinical Psychopharmacology and Neuroscience
2017 .01
-
Robot Motion Tracking Analysis in Attention-Deficit/Hyperactivity Disorder
대한소아청소년정신의학회 학술대회논문집
2017 .05
-
Initial Impact of the COVID-19 Outbreak on ADHD Symptoms Among University Students in Japan
소아청소년정신의학
2023 .04
-
한국형 성인 ADHD 평가척도 개발 연구
소아청소년정신의학
2015 .12
-
Psychopathologic Profiles and Clusters in Tertiary Clinic Referred Patients with Adult Attention Deficit Hyperactivity Disorder: A Person-Centered Analysis
PSYCHIATRY INVESTIGATION
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-516-001864331