지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 151 - 162 (12page)
이용수
초록· 키워드
오류제보하기
Anti-diabetes activity of Catharsius molossus (Ca, a type of dung beetle) glycosaminoglycan (G) was evaluated to reduce glucose, creatinine kinase, triglyceride and free fatty acid levels in db mice. Diabetic mice in six groups were administrated intraperitoneally: Db heterozygous (Normal), Db homozygous (CON), Heuchys sanguinea glycosaminoglycan (HEG, 5 mg/kg), dung beetle glycosaminoglycan (CaG, 5 mg/kg), bumblebee (Bombus ignitus) queen glycosaminoglycan (IQG, 5 mg/kg) and metformin (10 mg/kg), for 1 month. Biochemical analyses in the serum were evaluated to determine their anti-diabetic and anti-inflammatory actions in db mice after 1 month treatment with HEG, CaG or IQG treatments. Blood glucose level was decreased by treatment with CaG. CaG produced significant anti-diabetic actions by inhiting creatinine kinase and alkaline phosphatase levels. As diabetic parameters, serum glucose level, total cholesterol and triglyceride were significantly decreased in CaG5-treated group compared to the controls. Dung beetle glycosaminoglycan, compared to the control, could be a potential therapeutic agent with anti-diabetic activity in diabetic mice. CaG5-treated group, compared to the control, showed the up-regulation of 48 genes including mitochondrial yen coded tRNA lysine (mt-TK), cytochrome P450, family 8/2, subfamily b, polypeptide 1 (Cyp8b1), and down-regulation of 79 genes including S100 calcium binding protein A9 (S100a9) and immunoglobulin kappa chain complex (Igk), and 3-hydroxy-3-methylglutaryl-CoenzymeAsynthase1 (Hmgcs1). Moreover, mitochondrial thymidine kinase (mt-TK), was up-regulated, and calgranulin A (S100a9) were down-regulated by CaG5 treatment, indicating a potential therapeutic use for anti-diabetic agent.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Yan, W. / 2015 / Antioxidant and antithrombotic therapies for diabetic kidney disease / Iran. J. Kidney Dis. 9:413~420
Lepedda, A.J. / 2017 / Significance of urinary glycosaminoglycans/proteoglycans in the evaluation of type 1 and type 2 diabetes complications / J. Diabetes Complicat. 31:149~155
Kubaski, F. / 2017 / Glycosaminoglycans detection methods: application of mass spectrometry / Mol. Genet. Metab. 120:67~77
Li, R. / 2015 / Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review / Drug Des. Devel. Ther. 9:6275~6283
Ahn, M.Y. / 2017 / Anti-obesity effect of Bombus ignitus queen glycosaminoglycans in rats on a highfat diet / Int. J. Mol. Sci. 18:E681
Lepedda, A.J. / 2017 / Significance of urinary glycosaminoglycans/proteoglycans in the evaluation of type 1 and type 2 diabetes complications / J. Diabetes Complicat. 31:149~155
Kubaski, F. / 2017 / Glycosaminoglycans detection methods: application of mass spectrometry / Mol. Genet. Metab. 120:67~77
Li, R. / 2015 / Sulodexide therapy for the treatment of diabetic nephropathy, a meta-analysis and literature review / Drug Des. Devel. Ther. 9:6275~6283
Ahn, M.Y. / 2017 / Anti-obesity effect of Bombus ignitus queen glycosaminoglycans in rats on a highfat diet / Int. J. Mol. Sci. 18:E681
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UCI(KEPA) : I410-ECN-0101-2018-513-001920719