지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.10
- 수록면
- 244 - 250 (7page)
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초록· 키워드
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Background: Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3.
Methods: In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats.
Results: REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor-a (TNF-α)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls.
Conclusion: Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases.
Methods: In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats.
Results: REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor-a (TNF-α)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls.
Conclusion: Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (28)
참고문헌 신청
Harrison DG / 2011 / Inflammation, immunity, and hypertension / Hypertension 57:132~140
Panza JA / 1990 / Abnormal endotheliumdependent vascular relaxation in patients with essential hypertension / N Engl J Med 323:22~27
Panza JA / 1993 / Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension / Circulation 87:1468~1474
Walsh T / 2009 / Impaired endothelial nitric oxide bioavailability: a common link between aging, hypertension, and atherogenesis? / J Am Geriatr Soc 57:140~145
Conger JD / 1994 / Endothelial regulation of vascular tone / Hosp Pract (Off Ed) 29:117~122
Panza JA / 1990 / Abnormal endotheliumdependent vascular relaxation in patients with essential hypertension / N Engl J Med 323:22~27
Panza JA / 1993 / Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension / Circulation 87:1468~1474
Walsh T / 2009 / Impaired endothelial nitric oxide bioavailability: a common link between aging, hypertension, and atherogenesis? / J Am Geriatr Soc 57:140~145
Conger JD / 1994 / Endothelial regulation of vascular tone / Hosp Pract (Off Ed) 29:117~122
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UCI(KEPA) : I410-ECN-0101-2018-524-001597424