지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 107 - 115 (9page)
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초록· 키워드
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Background: Depression is one of the most commonly diagnosed neuropsychiatric diseases, but the underlying mechanism and medicine are not well-known. Although Panax ginseng has been reported to exert protective effects in various neurological studies, little information is available regarding its antidepressant effects.
Methods: Here, we examined the antidepressant effect and underlying mechanism of P. ginseng extract (PGE) in a chronic restraint stress (CRS)-induced depression model in mice.
Results: Oral administration of PGE for 14 d decreased immobility (depression-like behaviors) time in forced swim and tail suspended tests after CRS induction, which corresponded with attenuation of the levels of serum adrenocorticotropic hormone and corticosterone, as well as attenuated c-Fos expression in the amygdala. PGE enhanced messenger RNA expression level of brain-derived neurotrophic factor but ameliorated microglial activation and neuroinflammation (the level of messenger RNA and protein expression of cyclooxygenase-2 and inducible nitric oxide synthase) in the amygdala of mice after CRS induction. Interestingly, 14-d treatment with celecoxib, a selective cyclooxygenase-2 inhibitor, and N<SUB>ω</SUB>-nitro-L-arginine methyl ester hydrochloride, a selective inducible nitric oxide synthase inhibitor, attenuated depression-like behaviors after CRS induction. Additionally, PGE inhibited the upregulation of the nuclear factor erythroid 2 related factor 2 and heme oxygenase-1 pathways.
Conclusion: Taken together, our findings suggest that PGE exerts antidepressant-like effect of CRS-induced depression by antineuroinflammatory and antioxidant (nuclear factor erythroid 2 related factor 2/heme oxygenase-1 activation) activities by inhibiting the hypothalamo-pituitary-adrenal axis mechanism. Further studies are needed to evaluate the potential of components of P. ginseng as an alternative treatment of depression, including clinical trial evaluation.
Methods: Here, we examined the antidepressant effect and underlying mechanism of P. ginseng extract (PGE) in a chronic restraint stress (CRS)-induced depression model in mice.
Results: Oral administration of PGE for 14 d decreased immobility (depression-like behaviors) time in forced swim and tail suspended tests after CRS induction, which corresponded with attenuation of the levels of serum adrenocorticotropic hormone and corticosterone, as well as attenuated c-Fos expression in the amygdala. PGE enhanced messenger RNA expression level of brain-derived neurotrophic factor but ameliorated microglial activation and neuroinflammation (the level of messenger RNA and protein expression of cyclooxygenase-2 and inducible nitric oxide synthase) in the amygdala of mice after CRS induction. Interestingly, 14-d treatment with celecoxib, a selective cyclooxygenase-2 inhibitor, and N<SUB>ω</SUB>-nitro-L-arginine methyl ester hydrochloride, a selective inducible nitric oxide synthase inhibitor, attenuated depression-like behaviors after CRS induction. Additionally, PGE inhibited the upregulation of the nuclear factor erythroid 2 related factor 2 and heme oxygenase-1 pathways.
Conclusion: Taken together, our findings suggest that PGE exerts antidepressant-like effect of CRS-induced depression by antineuroinflammatory and antioxidant (nuclear factor erythroid 2 related factor 2/heme oxygenase-1 activation) activities by inhibiting the hypothalamo-pituitary-adrenal axis mechanism. Further studies are needed to evaluate the potential of components of P. ginseng as an alternative treatment of depression, including clinical trial evaluation.
목차
ABSTRACT
1. Introduction
2. Materials and materials
3. Results
4. Discussion
5. Conclusions
References
참고문헌 (54)
참고문헌 신청
[학술지(정기간행물)] - Lang UE / 2013 / Molecular mechanisms of depression: perspectives on new treatment strategies / Cell Physiol Biochem 31 : 761 ~ 777
[학술지(정기간행물)] - Krishnan V / 2008 / The molecular neurobiology of depression / Nature 455 : 894 ~ 902
[학술지(정기간행물)] - Bakunina N / 2015 / Immune mechanisms linked to depression via oxidative stress and neuroprogression / Immunology 144 : 365 ~ 373
[학술지(정기간행물)] - Henckens MJ / 2015 / Stress-induced alterations in large-scale functional networks of the rodent brain / Neuroimage 105 : 312 ~ 322
[학술지(정기간행물)] - Mitra R / 2008 / Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy / Proc Natl Acad Sci U S A 105 : 5573 ~ 5578
[학술지(정기간행물)] - Krishnan V / 2008 / The molecular neurobiology of depression / Nature 455 : 894 ~ 902
[학술지(정기간행물)] - Bakunina N / 2015 / Immune mechanisms linked to depression via oxidative stress and neuroprogression / Immunology 144 : 365 ~ 373
[학술지(정기간행물)] - Henckens MJ / 2015 / Stress-induced alterations in large-scale functional networks of the rodent brain / Neuroimage 105 : 312 ~ 322
[학술지(정기간행물)] - Mitra R / 2008 / Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy / Proc Natl Acad Sci U S A 105 : 5573 ~ 5578
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UCI(KEPA) : I410-ECN-0101-2018-524-001744618