A comparative study on chemical composition of total saponins extracted from fermented and white ginseng under the effect of macrophage phagocytotic function

Dan Xiao; Yang Xiu; Hao Yue; Xiuli Sun; Huanxi Zhao; Shuying Liu

A comparative study on chemical composition of total saponins extracted from fermented and white ginseng under the effect of macrophage phagocytotic function

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A comparative study on chemical composition of total saponins extracted from fermented and white ginseng under the effect of macrophage phagocytotic function

자료유형: 학술저널

저자정보: Dan Xiao (Chang Chun University of Technology) Yang Xiu (Chang Chun University of Chinese Medicine) Hao Yue (Chang Chun University of Chinese Medicine) Xiuli Sun (Chang Chun University of Chinese Medicine) Huanxi Zhao (Chang Chun University of Chinese Medicine) Shuying Liu (Chang Chun University of Technology)

저널정보: 고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.41 No.3 KCI Candidated Journals SCIE

발행연도: 2017.7

수록면: 379 - 385 (7page)

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A comparative study on chemical composition of total saponins extracted from fermented and white ginseng under the effect of macrophage phagocytotic function

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In this study, white ginseng was used as the raw material, which was fermented with Paecilomyces hepiali through solid culture medium, to produce ginsenosides with modified chemical composition. The characteristic chemical markers of the products thus produced were investigated using rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (RRLCeQTOFeMS). Chemical profiling data were obtained, which were then subjected to multivariate statistical analysis for the systematic comparison of active ingredients in white ginseng and fermented ginseng to understand the beneficial properties of ginsenoside metabolites. In addition, the effects of these components on biological activity were investigated to understand the improvements in the phagocytic function of macrophages in zebrafish. According to the established RRLCeQTOFeMS chemical profiling, the contents in ginsenosides of high molecular weight, especially malonylated protopanaxadiol ginsenosides, were slightly reduced due to the fermentation, which were hydrolyzed into rare and minor ginsenosides. Moreover, the facilitation of macrophage phagocytic function in zebrafish following treatment with different ginseng extracts confirmed that the fermented ginseng is superior to white ginseng. Our results prove that there is a profound change in chemical constituents of ginsenosides during the fermentation process, which has a significant effect on the biological activity of these compounds.

#chemical variation #content #fermented #ginseng #ginsenosides

참고문헌 (20)

참고문헌 신청

[학술지(정기간행물)] - Pu Z / 2011 / The evaluation of contents of nine ginsenoside monomers in ginseng hairy roots by high performance liquid chromatography(HPLC) / J Med Plant Res 5 : 5513 ~ 5516

[학술지(정기간행물)] - Gui Ying / 2013 / The effect of extrusion conditions on the acidic polysaccharide, ginsenoside contents and antioxidant properties of extruded Korean red ginseng / Journal of Ginseng Research 37 (2) : 219 ~ 226

[학술지(정기간행물)] - Ligor T / 2005 / Isolation and determination of ginsenosides in American ginseng leaves and root extracts by LC-MS / Anal Bioanal Chem 383 : 1098 ~ 1105

[학술지(정기간행물)] - Ahnso HY / 2013 / Panax ginseng extract rich in ginsenoside protopanaxatriol offers combinatorial effects in nitric oxide production via multiple signaling pathways / Springerplus 2 : 96 ~ 100

[학술지(정기간행물)] - Hien TT / 2010 / Ginsenoside Rg3increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase : essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase / Toxicol Appl Pharmacol 246 : 171 ~ 183

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이 논문의 저자 정보

Dan Xiao

소속기관 Changchun University of Technology

주요연구분야 의약학 > 기타 의약학

논문수 3 이용수 9

Yang Xiu