지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 503 - 512 (10page)
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초록· 키워드
오류제보하기
Background: Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats.
Methods: LongeEvans Tokushima Fatty (LETO) and Otsuka LongeEvans Tokushima Fatty (OLETF) rats were pair-fed a LiebereDeCarli diet with and without 5% ethanol for 12 wks. Two weeks after starting the pair-feeding with the LiebereDeCarli diet, intraperitoneal injection of saponin was performed for 10 wks. To perform the experiments, rats were divided as follows: LETO-Control (LC), LETO-Ethanol (LE), LETOEthanol-Saponin (LES), OLETF-Control (OC), OLETF-Ethanol (OE), and OLETF-Ethanol-Saponin (OES).
Results: The weights of epididymal and mesenteric fat tissue in LES and OES rats were the lightest from among the LETO and OLETF groups, respectively. The secretion of alanine aminotransferase and cholesterol in OES rats decreased significantly compared to their secretion in OC and OE rats, respectively. The islets of the pancreas in LE and OE rats showed clean, unclear, and smaller morphology compared to those of LC, LES, OC, and OES rats. In addition, the expression of insulin in the islets of the pancreas in LC, LES, OC, and OES rats was higher than in LE and OE rats.
Conclusion: Saponin may not only be helpful in alleviating the rapid progress of diabetes due to chronic alcohol consumption in diabetic patients, but may also show potential as an antidiabetic drug candidate for diabetic patients who chronically consume alcohol.
Methods: LongeEvans Tokushima Fatty (LETO) and Otsuka LongeEvans Tokushima Fatty (OLETF) rats were pair-fed a LiebereDeCarli diet with and without 5% ethanol for 12 wks. Two weeks after starting the pair-feeding with the LiebereDeCarli diet, intraperitoneal injection of saponin was performed for 10 wks. To perform the experiments, rats were divided as follows: LETO-Control (LC), LETO-Ethanol (LE), LETOEthanol-Saponin (LES), OLETF-Control (OC), OLETF-Ethanol (OE), and OLETF-Ethanol-Saponin (OES).
Results: The weights of epididymal and mesenteric fat tissue in LES and OES rats were the lightest from among the LETO and OLETF groups, respectively. The secretion of alanine aminotransferase and cholesterol in OES rats decreased significantly compared to their secretion in OC and OE rats, respectively. The islets of the pancreas in LE and OE rats showed clean, unclear, and smaller morphology compared to those of LC, LES, OC, and OES rats. In addition, the expression of insulin in the islets of the pancreas in LC, LES, OC, and OES rats was higher than in LE and OE rats.
Conclusion: Saponin may not only be helpful in alleviating the rapid progress of diabetes due to chronic alcohol consumption in diabetic patients, but may also show potential as an antidiabetic drug candidate for diabetic patients who chronically consume alcohol.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (46)
참고문헌 신청
[학술지(정기간행물)] - Hodge AM / 1993 / Abnormal glucose tolerance and alcohol consumption in three populations at high risk of non-insulindependent diabetes mellitus / Am J Epidemiol 137 : 178 ~ 189
[학술지(정기간행물)] - Patel SB / 2015 / Anti-diabetic effects of ethanol extract of Bryonia laciniosa seeds and its saponins rich fraction in neonatally streptozotocin-induced diabetic rats / Pharmacognosy Res 7 : 92 ~ 99
[학술지(정기간행물)] - Kim JY / 2013 / In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated beta-cell dysfunction during the progression of type-2 diabetes / Cell Signal 25 : 2348 ~ 2361
[학술지(정기간행물)] - Ozcan U / 2004 / Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes / Science 306 : 457 ~ 461
[학술지(정기간행물)] - Reynolds K / 2003 / Alcohol consumption and risk of stroke : a meta-analysis / JAMA 289 : 579 ~ 588
[학술지(정기간행물)] - Patel SB / 2015 / Anti-diabetic effects of ethanol extract of Bryonia laciniosa seeds and its saponins rich fraction in neonatally streptozotocin-induced diabetic rats / Pharmacognosy Res 7 : 92 ~ 99
[학술지(정기간행물)] - Kim JY / 2013 / In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated beta-cell dysfunction during the progression of type-2 diabetes / Cell Signal 25 : 2348 ~ 2361
[학술지(정기간행물)] - Ozcan U / 2004 / Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes / Science 306 : 457 ~ 461
[학술지(정기간행물)] - Reynolds K / 2003 / Alcohol consumption and risk of stroke : a meta-analysis / JAMA 289 : 579 ~ 588
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UCI(KEPA) : I410-ECN-0101-2018-524-001599266