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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.93 No.5
- 발행연도
- 2017.11
- 수록면
- 240 - 245 (6page)
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Purpose: Various methods of sentinel lymph node (SLN) biopsy in thyroid cancer have been introduced. Tc-99m phytate as a radiotracer has been successfully utilized for SLN biopsy in breast, cervix, and endometrial cancer. We assessed the feasibility of SLN dissection using Tc-99m phytate in papillary thyroid carcinoma (PTC).
Methods: Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed. Preoperative single-photon emission-computed tomography (SPECT) and intraoperative gamma-probe were used for SLN detection during operation.
Results: Identification rate of SLNs was 70.6% (12 of 17) with SPECT, and 88.2% (15 of 17) with gamma-probe. Combined SPECT and gamma-probe had identification rates of 88.2% (15 of 17). Identification rates of SLNs in central LN compartments were 82.4% (14 of 17) and 41.2% (7 of 17) in lateral LN compartments. Overall sensitivity, specificity, positive predictive value, and negative predictive value of the results of SLN biopsy were 91.6%, 100%, 88.4%, and 100%, respectively. Eight patients (47.1%) had metastasis in SLNs; all patients had SLN metastasis in the central compartment and 2 patients had SLN metastasis in both the central and lateral compartments.
Conclusion: Combined SPECT and gamma-probe could detect SLNs with an 88.2% identification rate in PTC. SLN biopsy using Tc-99m phytate is technically feasible. Further investigation is warranted for clinical application of Tc-99m phytate in PTC.
Methods: Seventeen patients with PTC were prospectively enrolled. Ultrasound-guided peritumoral injection of 55.5 MBq Tc-99m phytate in 0.25-mL normal saline was performed. Preoperative single-photon emission-computed tomography (SPECT) and intraoperative gamma-probe were used for SLN detection during operation.
Results: Identification rate of SLNs was 70.6% (12 of 17) with SPECT, and 88.2% (15 of 17) with gamma-probe. Combined SPECT and gamma-probe had identification rates of 88.2% (15 of 17). Identification rates of SLNs in central LN compartments were 82.4% (14 of 17) and 41.2% (7 of 17) in lateral LN compartments. Overall sensitivity, specificity, positive predictive value, and negative predictive value of the results of SLN biopsy were 91.6%, 100%, 88.4%, and 100%, respectively. Eight patients (47.1%) had metastasis in SLNs; all patients had SLN metastasis in the central compartment and 2 patients had SLN metastasis in both the central and lateral compartments.
Conclusion: Combined SPECT and gamma-probe could detect SLNs with an 88.2% identification rate in PTC. SLN biopsy using Tc-99m phytate is technically feasible. Further investigation is warranted for clinical application of Tc-99m phytate in PTC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Shaha AR. / 1998 / Management of the neck in thyroid cancer / Otolaryngol Clin North Am 31 : 823 ~ 831
[학술지(정기간행물)] - McHenry CR / 1991 / Prospective management of nodal metastases in differentiated thyroid cancer / Am J Surg 162 : 353 ~ 356
[학술지(정기간행물)] - Coburn MC / 1992 / Prognostic factors and management considerations in patients with cervical metastases of thyroid cancer / Am J Surg 164 : 671 ~ 676
[학술지(정기간행물)] - Hughes CJ / 1996 / Impact of lymph node metastasis in differentiated carcinoma of the thyroid : a matched-pair analysis / Head Neck 18 : 127 ~ 132
[학술지(정기간행물)] - Eichhorn W / 2003 / Prognostic factors determining long-term survival in well-differentiated thyroid cancer : an analysis of four hundred eightyfour patients undergoing therapy and aftercare at the same institution / Thyroid 13 : 949 ~ 958
[학술지(정기간행물)] - McHenry CR / 1991 / Prospective management of nodal metastases in differentiated thyroid cancer / Am J Surg 162 : 353 ~ 356
[학술지(정기간행물)] - Coburn MC / 1992 / Prognostic factors and management considerations in patients with cervical metastases of thyroid cancer / Am J Surg 164 : 671 ~ 676
[학술지(정기간행물)] - Hughes CJ / 1996 / Impact of lymph node metastasis in differentiated carcinoma of the thyroid : a matched-pair analysis / Head Neck 18 : 127 ~ 132
[학술지(정기간행물)] - Eichhorn W / 2003 / Prognostic factors determining long-term survival in well-differentiated thyroid cancer : an analysis of four hundred eightyfour patients undergoing therapy and aftercare at the same institution / Thyroid 13 : 949 ~ 958
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UCI(KEPA) : I410-ECN-0101-2018-514-001438066